Fetal Alcohol Syndrome Prevention Center, Ewha Mokdong Hospital, Ewha Womans University, Seoul 07985, Korea.
Department of Obstetrics & Gynecology, Ewha Womans University, Seoul 07985, Korea.
Int J Environ Res Public Health. 2020 Nov 17;17(22):8515. doi: 10.3390/ijerph17228515.
For women who suffer from Alcohol Use Disorders (AUDs), the use of alcohol before and/or during pregnancy may result in various birth complications, including miscarriage, stillbirth, or preterm delivery. Thus, this study aimed to explore whether Alcohol Use Disorders (AUDs) are associated with increased risk of adverse birth complications and outcomes. A total of 76,799 deliveries between 2003 and 2013 in the Korean National Health Insurance Service National Sample Cohort (NHIS-NSC) were analyzed. Women with an AUD diagnosis preceding delivery were identified as individuals with alcohol dependence. A multivariate Cox proportional hazards model was used to estimate the hazard ratio of adverse birth complications and outcomes associated with alcohol dependence. Diagnosis of an AUD was associated with increased risk of adverse birth complications (Hazard Ratio [HR]: 1.15, 95% CI: 1.01-1.31, = 0.0302). This was especially the case for women whose AUD diagnosis was in the same year as their delivery (HR: 1.53, 95% CI: 1.24-1.88, < 0.0001). AUDs were associated with increased risk of adverse birth outcomes, especially when prevalent in the same year as a woman's delivery. Our study confirms that the monitoring of expecting women with a diagnosis of alcohol-related problems may be useful in preventing adverse birth complications.
对于患有酒精使用障碍（AUD）的女性，在怀孕前和/或怀孕期间饮酒可能会导致各种分娩并发症，包括流产、死产或早产。因此，本研究旨在探讨 AUD 是否与增加不良分娩并发症和结局的风险有关。分析了 2003 年至 2013 年期间在韩国国家健康保险服务国家样本队列（NHIS-NSC）中进行的 76799 次分娩。在分娩前被诊断为 AUD 的女性被认定为有酒精依赖的个体。使用多变量 Cox 比例风险模型来估计与酒精依赖相关的不良分娩并发症和结局的风险比。AUD 的诊断与不良分娩并发症的风险增加相关（风险比[HR]：1.15，95%CI：1.01-1.31， = 0.0302）。对于 AUD 诊断与分娩同年的女性，这种情况尤其如此（HR：1.53，95%CI：1.24-1.88，<0.0001）。AUD 与不良分娩结局的风险增加有关，尤其是在女性分娩同年时更为明显。本研究证实，对诊断为与酒精相关问题的孕妇进行监测可能有助于预防不良分娩并发症。
