Li Peijun, Terrett Jack A, Zbieg Jason R
Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
ACS Med Chem Lett. 2020 Sep 21;11(11):2120-2130. doi: 10.1021/acsmedchemlett.0c00436. eCollection 2020 Nov 12.
Visible light-mediated photocatalysis, which relies on the ability of photocatalysts to absorb low-energy visible light and engage in single-electron transfer (SET) or energy transfer (ET) processes with organic substrates, has emerged as one of the fastest growing fields in organic synthesis. This catalytic platform enables a highly selective approach to promote radical-based organic transformations which unlocks unique reaction pathways. Due to the extremely mild conditions of these transformations and compatibility in aqueous environments, photocatalysis has emerged as an enabling technology in drug discovery. Photocatalysis is uniquely positioned for application in pharmaceutical development because of its demonstrated potential for broad functional group tolerance, biocompatibility, site-specific selectivity, and operational simplicity. This review will highlight the recent advances of visible-light photocatalysis through its application in peptide functionalization, protein bioconjugation, C -C cross-coupling, late-stage functionalization, isotopic labeling, DNA-encoded library technology (DELT), and microenvironment mapping (μMap).
可见光介导的光催化依赖于光催化剂吸收低能量可见光并与有机底物进行单电子转移（SET）或能量转移（ET）过程的能力，已成为有机合成中发展最快的领域之一。这个催化平台提供了一种高度选择性的方法来促进基于自由基的有机转化，从而开启独特的反应途径。由于这些转化条件极其温和且在水性环境中具有兼容性，光催化已成为药物发现中的一项赋能技术。光催化因其在广泛的官能团耐受性、生物相容性、位点特异性选择性和操作简便性方面已展现出的潜力，在药物开发中具有独特的应用地位。本综述将重点介绍可见光光催化在肽功能化、蛋白质生物共轭、C-C交叉偶联、后期功能化、同位素标记、DNA编码文库技术（DELT）和微环境映射（μMap）中的应用所取得的最新进展。
