Park Su Hwan, Che Cheng-Ye, Kim Sung Il, Park Choul Yong, Lee Jong Heon, Kim Young Hee, Jung Ji Won, Lee Jong Soo, Lee Ji Eun
Department of Ophthalmology, School of Medicine, Pusan National University, Yangsan 50612, Gyeongnam Province, Republic of Korea.
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Gyeongnam Province, Republic of Korea.
Int J Ophthalmol. 2020 Nov 18;13(11):1780-1787. doi: 10.18240/ijo.2020.11.15. eCollection 2020.
To compare the clinical results of femtosecond (FS) laser keratomileusis (LASIK) in high myopic patients and low myopic patients.
This study included 212 myopic eyes undergoing LASIK using a VisuMax 500kHz FS laser. All treated eyes were assigned to one of two groups according to preoperative manifest spherical refraction: low myopia group (A, >-4.0 D) and high myopia group (B, ≤-4.0 D). Uncorrected and corrected distance visual acuity (UDVA, CDVA), refractive errors, and higher-order aberrations (HOAs) were measured preoperatively and 1wk, 1, 3 and 6mo postoperatively.
At 6mo of follow-up, 92% and 76% had a UDVA of 20/20 or better in group A and B, respectively (=0.037) and UDVA was significantly different between two groups (=0.042). Six and seven percentage lost one line of CDVA in group A and B, respectively (=0.572) and no eyes in both groups lost more than two lines. Each group had 87% and 76% of treated eyes within ±0.5 D of the intended correction (=0.186), and 13% and 43% with a change of >0.50 D in spherical equivalent from 1wk to 6mo postoperatively (=0.005). In terms of postoperative astigmatism, each group had 89.1% and 76.6% within ±0.50 D, respectively and there was significant difference (=0.006). Group A tends to induce smaller HOAs than group B.
FS LASIK is effective and safe for correcting high myopia as well as low myopia. However, high myopic eyes showed more postoperative astigmatism and HOAs which affect visual acuity.
比较飞秒（FS）激光原位角膜磨镶术（LASIK）治疗高度近视患者和低度近视患者的临床效果。
本研究纳入了212只接受使用VisuMax 500kHz FS激光进行LASIK手术的近视眼睛。根据术前明显球镜屈光度，所有接受治疗的眼睛被分为两组之一：低度近视组（A组，>-4.0 D）和高度近视组（B组，≤-4.0 D）。术前及术后1周、1个月、3个月和6个月测量未矫正和矫正远视力（UDVA、CDVA）、屈光不正和高阶像差（HOAs）。
随访6个月时，A组和B组分别有92%和76%的患者UDVA达到20/20或更好（P=0.037），两组间UDVA有显著差异（P=0.042）。A组和B组分别有6%和7%的患者CDVA下降一行（P=0.572），两组均无眼睛CDVA下降超过两行。每组分别有87%和76%的治疗眼在预期矫正的±0.5 D范围内（P=0.186），术后1周至6个月，分别有13%和43%的患者等效球镜变化>0.50 D（P=0.005）。在术后散光方面，每组分别有89.1%和76.6%的患者在±0.50 D范围内，差异有统计学意义（P=0.006）。A组诱导的HOAs往往比B组小。
FS LASIK矫正高度近视和低度近视均有效且安全。然而，高度近视眼睛术后散光和HOAs更多，影响视力。
