Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, the Netherlands.
Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam, the Netherlands.
Alzheimers Dement. 2021 Feb;17(2):255-270. doi: 10.1002/alz.12188. Epub 2020 Nov 20.
Non-pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with dementia, but research often lacks methodological rigor and continues to produce mixed results.
In the current position paper, experts in NPT research have specified treatment targets, aims, and ingredients using an umbrella framework, the Rehabilitation Treatment Specification System.
Experts provided a snapshot and an authoritative summary of the evidence for different NPTs based on the best synthesis efforts, identified main gaps in knowledge and relevant barriers, and provided directions for future research. Experts in trial methodology provide best practice principles and recommendations for those working in this area, underscoring the importance of prespecified protocols.
We conclude that the evidence strongly supports various NPTs in relation to their primary targets, and discuss opportunities and challenges associated with a unifying theoretical framework to guide future efforts in this area.
非药物治疗（NPTs）有可能改善有痴呆风险或患有痴呆症的老年人的有意义的结局，但研究往往缺乏方法学严谨性，并且仍在产生混合结果。
在当前的立场文件中，NPT 研究专家使用伞式框架——康复治疗规范系统，指定了治疗目标、目的和成分。
专家根据最佳综合研究成果，提供了不同 NPT 的快照和权威总结，并确定了主要知识差距和相关障碍，并为未来的研究提供了方向。试验方法学专家为该领域的工作者提供了最佳实践原则和建议，强调了预设方案的重要性。
我们的结论是，有证据强烈支持各种 NPT 与其主要目标相关，并且讨论了与统一理论框架相关的机会和挑战，以指导该领域未来的努力。
