海洋天然产物生物合成研究的近期亮点。

Recent highlights of biosynthetic studies on marine natural products.

机构信息

Junior Research Group Chemical Biology of Microbe-Host Interactions, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstr. 11a, 07745 Jena, Germany.

出版信息

Org Biomol Chem. 2021 Jan 6;19(1):123-140. doi: 10.1039/d0ob01677b.

DOI:10.1039/d0ob01677b

PMID:33216100

Abstract

Marine bacteria are excellent yet often underexplored sources of structurally unique bioactive natural products. In this review we cover the diversity of marine bacterial biomolecules and highlight recent studies on structurally novel natural products. We include different compound classes and discuss the latest progress related to their biosynthetic pathway analysis and engineering: examples range from fatty acids over terpenes to PKS, NRPS and hybrid PKS-NRPS biomolecules.

摘要

海洋细菌是结构独特的生物活性天然产物的极佳但往往未被充分开发的来源。在这篇综述中，我们介绍了海洋细菌生物分子的多样性，并重点介绍了最近关于结构新颖天然产物的研究。我们包括了不同的化合物类别，并讨论了与其生物合成途径分析和工程相关的最新进展：例子从脂肪酸到萜类、聚酮合酶 (PKS)、非核糖体肽合酶 (NRPS) 和混合 PKS-NRPS 生物分子都有涵盖。