Department of Radiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Department of Diagnostic Imaging, The Cancer Institute Hospital Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto, Tokyo, 135-8550, Japan.
Jpn J Radiol. 2021 Apr;39(4):357-366. doi: 10.1007/s11604-020-01072-7. Epub 2020 Nov 20.
To clarify imaging and clinical characteristics of ovarian carcinosarcoma (CS) compared with high-grade serous carcinoma (HGSC).
We retrospectively reviewed MR imagings of 12 patients with CS and 30 patients with HGSC and evaluated tumor size, shape, appearance, nature of cystic and solid components, hemorrhage, and necrosis. Age, premenopausal or postmenopausal, histologic subtype, presence of endometriosis, tumor markers, and stage were also evaluated. These parameters were compared using the Mann-Whitney U test and the chi-square test/Fisher's exact test.
The mean size of CSs was 13.6 cm, and significantly larger than that of HGSCs (mean 9.0 cm, p = 0.022). The stained-glass appearance (67% vs. 23%, p = 0.013), hemorrhage (100% vs. 50%, p = 0.003), necrosis (75.0% vs. 13%, p = 0.000), and endometriosis (33% vs. 7%, p = 0.012) were significantly more common in CSs. The postmenopausal ratio of CSs was 100% and significantly higher than that of HGSCs (70.0%, p = 0.041). Among the tumor makers, only CA-125 was significantly lower in CSs than in HGSCs (mean 715.1 U/ml vs. 1677.1 U/ml, p = 0.009). The stage distribution was similar and was not significantly different.
CSs formed larger masses, and the stained-glass appearance, hemorrhage, and necrosis were more frequently observed in CSs.
与高级别浆液性癌（HGSC）相比，明确卵巢癌肉瘤（CS）的影像学和临床特征。
我们回顾性分析了 12 例 CS 和 30 例 HGSC 患者的磁共振成像（MRI）资料，评估了肿瘤的大小、形状、外观、囊实性成分的性质、出血和坏死情况。还评估了患者的年龄、绝经前或绝经后、组织学亚型、子宫内膜异位症的存在、肿瘤标志物和分期。使用 Mann-Whitney U 检验和卡方检验/Fisher 确切概率法比较这些参数。
CS 的平均大小为 13.6cm，明显大于 HGSC（平均 9.0cm，p=0.022）。CS 更常见的特征有染色玻璃外观（67%比 23%，p=0.013）、出血（100%比 50%，p=0.003）、坏死（75.0%比 13%，p=0.000）和子宫内膜异位症（33%比 7%，p=0.012）。CS 的绝经后比例为 100%，明显高于 HGSC（70.0%，p=0.041）。在肿瘤标志物中，只有 CA-125 在 CS 中明显低于 HGSC（平均值 715.1 U/ml 比 1677.1 U/ml，p=0.009）。分期分布相似，无显著差异。
CS 形成的肿块较大，CS 中更常出现染色玻璃外观、出血和坏死。
