Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China.
School of Pharmacy, Jining Medical College, Jining, Shandong 276800, P. R. China.
Org Lett. 2020 Dec 4;22(23):9346-9350. doi: 10.1021/acs.orglett.0c03565. Epub 2020 Nov 20.
Four unusual cyclopeptides, zelkovamycins B-E (-), were isolated from an endophytic sp. Zelkovamycin B was featured by an unprecedented 3-methyl-5-hydroxypyrrolidine-2,4-dione ring system linked to the cyclopeptide skeleton. Their structures and full configurations were established by spectroscopic analysis, Marfey's method, and NMR calculations. A plausible biosynthetic pathway for zelkovamycins was proposed based on gene cluster analysis. Zelkovamycin E displayed potent inhibitory activity against H1N1 influenza A virus.
四种不寻常的环肽，泽拉考霉素 B-E（-），从一种内生菌中分离得到。泽拉考霉素 B 的特点是具有前所未有的 3-甲基-5-羟基吡咯烷-2,4-二酮环系统与环肽骨架相连。通过光谱分析、马费里方法和 NMR 计算确定了它们的结构和全构型。基于基因簇分析提出了泽拉考霉素的可能生物合成途径。泽拉考霉素 E 对 H1N1 流感病毒表现出强烈的抑制活性。
