University of Montpellier, Institut de Génétique Moléculaire de Montpellier, CNRS, Montpellier, France.
University of Montpellier, Institut de Génétique Moléculaire de Montpellier, CNRS, Montpellier, France; Pediatric Oncology Branch, NCI, CCR, NIH, Bethesda, MD, USA.
Mol Cell. 2020 Nov 19;80(4):555-557. doi: 10.1016/j.molcel.2020.11.005.
In this issue of Molecular Cell, Byun et al. (2020) find that the dual targeting of glutamine metabolism and the PD-L1 checkpoint inhibitor augments anti-tumor immunity. Mechanistically, decreased glutamine availability attenuated S-glutathionylation of SERCA, resulting in an increase in cytosolic calcium, enhanced NF-κB activity, and upregulation of programmed death-ligand 1.
在本期《分子细胞》中，Byun 等人（2020 年）发现，靶向谷氨酰胺代谢和 PD-L1 检查点抑制剂的双重作用可以增强抗肿瘤免疫。从机制上讲，谷氨酰胺供应减少会减弱 SERCA 的 S-谷胱甘肽化，导致细胞浆钙增加、NF-κB 活性增强和程序性死亡配体 1 的上调。
