围手术期挥发性麻醉剂对吞噬细胞影响的作用机制研究。
Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes.
机构信息
Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Clin Immunol. 2021 Jan;222:108635. doi: 10.1016/j.clim.2020.108635. Epub 2020 Nov 17.
Abstract
A growing literature has shown that volatile anesthetics are promiscuous molecules targeting multiple molecules, some of which are critical for immunological functions. We focused on studies that delineated target molecules of volatile anesthetics on immune cells and summarized the effects of volatile anesthetics on immune functions. We also presented the perspectives of studying volatile anesthetics-mediated immunomodulation.
摘要
越来越多的文献表明，挥发性麻醉剂是一种混杂的分子，针对多种分子，其中一些对于免疫功能至关重要。我们专注于研究挥发性麻醉剂在免疫细胞上的靶分子，并总结了挥发性麻醉剂对免疫功能的影响。我们还提出了研究挥发性麻醉剂介导的免疫调节的观点。
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本文引用的文献
1
Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation.挥发性麻醉剂七氟醚可减弱 Toll 样受体 1/2 的激活。
Anesth Analg. 2020 Aug;131(2):631-639. doi: 10.1213/ANE.0000000000004741.
2
Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system.挥发性麻醉剂异氟烷和七氟烷直接靶向并减弱 Toll 样受体 4 系统。
FASEB J. 2019 Dec;33(12):14528-14541. doi: 10.1096/fj.201901570R. Epub 2019 Nov 2.
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Volatile anesthetics affect macrophage phagocytosis.挥发性麻醉剂会影响巨噬细胞的吞噬作用。
PLoS One. 2019 May 9;14(5):e0216163. doi: 10.1371/journal.pone.0216163. eCollection 2019.
4
The Use of Volatile Anesthetics as Sedatives for Acute Respiratory Distress Syndrome.挥发性麻醉剂作为急性呼吸窘迫综合征镇静剂的应用
Transl Perioper Pain Med. 2019;6(2):27-38. doi: 10.31480/2330-4871/084. Epub 2019 Feb 21.
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Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa.神经免疫相互作用：从大脑到免疫系统，反之亦然。
Physiol Rev. 2018 Jan 1;98(1):477-504. doi: 10.1152/physrev.00039.2016.
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