• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

围手术期挥发性麻醉剂对吞噬细胞影响的作用机制研究。

Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes.

机构信息

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Clin Immunol. 2021 Jan;222:108635. doi: 10.1016/j.clim.2020.108635. Epub 2020 Nov 17.

DOI:10.1016/j.clim.2020.108635
PMID:33217544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7856197/
Abstract

A growing literature has shown that volatile anesthetics are promiscuous molecules targeting multiple molecules, some of which are critical for immunological functions. We focused on studies that delineated target molecules of volatile anesthetics on immune cells and summarized the effects of volatile anesthetics on immune functions. We also presented the perspectives of studying volatile anesthetics-mediated immunomodulation.

摘要

越来越多的文献表明,挥发性麻醉剂是一种混杂的分子,针对多种分子,其中一些对于免疫功能至关重要。我们专注于研究挥发性麻醉剂在免疫细胞上的靶分子,并总结了挥发性麻醉剂对免疫功能的影响。我们还提出了研究挥发性麻醉剂介导的免疫调节的观点。

相似文献

1
Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes.围手术期挥发性麻醉剂对吞噬细胞影响的作用机制研究。
Clin Immunol. 2021 Jan;222:108635. doi: 10.1016/j.clim.2020.108635. Epub 2020 Nov 17.
2
Volatile anesthetics affect macrophage phagocytosis.挥发性麻醉剂会影响巨噬细胞的吞噬作用。
PLoS One. 2019 May 9;14(5):e0216163. doi: 10.1371/journal.pone.0216163. eCollection 2019.
3
Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction.用挥发性麻醉剂预处理的中性粒细胞会丧失导致心脏功能障碍的能力。
Anesthesiology. 2003 Mar;98(3):712-8. doi: 10.1097/00000542-200303000-00020.
4
Effects of volatile anesthetics on circadian rhythm in mice: a comparative study of sevoflurane, desflurane, and isoflurane.挥发性麻醉剂对小鼠昼夜节律的影响:七氟醚、地氟醚和异氟醚的比较研究。
J Anesth. 2024 Feb;38(1):10-18. doi: 10.1007/s00540-023-03262-9. Epub 2023 Sep 24.
5
Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation.挥发性麻醉剂七氟醚可减弱 Toll 样受体 1/2 的激活。
Anesth Analg. 2020 Aug;131(2):631-639. doi: 10.1213/ANE.0000000000004741.
6
Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system.挥发性麻醉剂异氟烷和七氟烷直接靶向并减弱 Toll 样受体 4 系统。
FASEB J. 2019 Dec;33(12):14528-14541. doi: 10.1096/fj.201901570R. Epub 2019 Nov 2.
7
Effects of Volatile Anesthetics on Proliferation and Viability of SW480 Colon Cancer Cells .挥发性麻醉剂对 SW480 结肠癌细胞增殖和活力的影响。
Anticancer Res. 2019 Nov;39(11):6049-6055. doi: 10.21873/anticanres.13811.
8
Inhaled Anesthetics Exert Different Protective Properties in a Mouse Model of Ventilator-Induced Lung Injury.吸入麻醉药在呼吸机诱导的肺损伤小鼠模型中发挥不同的保护作用。
Anesth Analg. 2016 Jul;123(1):143-51. doi: 10.1213/ANE.0000000000001296.
9
Effects of volatile anaesthetics on human neutrophil oxidative response to the bacterial peptide FMLP.
Br J Anaesth. 1997 Jun;78(6):718-23. doi: 10.1093/bja/78.6.718.
10
The role of astrocytic γ-aminobutyric acid in the action of inhalational anesthetics.星形细胞γ-氨基丁酸在吸入麻醉剂作用中的角色。
Eur J Pharmacol. 2024 May 5;970:176494. doi: 10.1016/j.ejphar.2024.176494. Epub 2024 Mar 12.

引用本文的文献

1
Prolonged in vitro anti-bacterial, anti-inflammatory, and surfactant-promoting effects of volatile anesthetics.挥发性麻醉剂的体外抗菌、抗炎和促进表面活性剂作用的延长效应。
BMC Pulm Med. 2025 Sep 9;25(1):425. doi: 10.1186/s12890-025-03849-w.
2
The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel.THIK1双孔钾通道麻醉抑制作用的冷冻电镜结构及物理基础
Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2421654122. doi: 10.1073/pnas.2421654122. Epub 2025 Apr 3.
3
Inhalation Anesthetics Play a Janus-Faced Role in Self-Renewal and Differentiation of Stem Cells.

本文引用的文献

1
Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation.挥发性麻醉剂七氟醚可减弱 Toll 样受体 1/2 的激活。
Anesth Analg. 2020 Aug;131(2):631-639. doi: 10.1213/ANE.0000000000004741.
2
Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system.挥发性麻醉剂异氟烷和七氟烷直接靶向并减弱 Toll 样受体 4 系统。
FASEB J. 2019 Dec;33(12):14528-14541. doi: 10.1096/fj.201901570R. Epub 2019 Nov 2.
3
Volatile anesthetics affect macrophage phagocytosis.挥发性麻醉剂会影响巨噬细胞的吞噬作用。
吸入麻醉剂在干细胞的自我更新和分化中扮演着双面角色。
Biomolecules. 2024 Sep 18;14(9):1167. doi: 10.3390/biom14091167.
4
Immunopharmacological considerations of general anaesthetics for surgical procedures in the times of COVID-19: Correspondence.2019年冠状病毒病疫情期间手术操作中全身麻醉药的免疫药理学考量:通信
Ann Med Surg (Lond). 2023 Apr 6;85(5):2232-2236. doi: 10.1097/MS9.0000000000000555. eCollection 2023 May.
5
Systemic immune effects of anesthetics and their intracellular targets in tumors.麻醉剂在肿瘤中的全身免疫效应及其细胞内靶点
Front Med (Lausanne). 2022 Jul 28;9:810189. doi: 10.3389/fmed.2022.810189. eCollection 2022.
6
Desflurane improves lung collapse more than propofol during one-lung ventilation and reduces operation time in lobectomy by video-assisted thoracic surgery: a randomized controlled trial.地氟醚在单肺通气期间比异丙酚更能改善肺萎陷,并通过电视辅助胸腔镜手术减少肺叶切除术的手术时间:一项随机对照试验。
BMC Anesthesiol. 2022 Apr 29;22(1):125. doi: 10.1186/s12871-022-01669-7.
7
The Role of General Anesthetic Drug Selection in Cancer Outcome.全身麻醉药物选择在癌症转归中的作用。
Biomed Res Int. 2021 Oct 7;2021:2563093. doi: 10.1155/2021/2563093. eCollection 2021.
8
The immunomodulatory mechanism of dexmedetomidine.右美托咪定的免疫调节机制。
Int Immunopharmacol. 2021 Aug;97:107709. doi: 10.1016/j.intimp.2021.107709. Epub 2021 Apr 29.
PLoS One. 2019 May 9;14(5):e0216163. doi: 10.1371/journal.pone.0216163. eCollection 2019.
4
The Use of Volatile Anesthetics as Sedatives for Acute Respiratory Distress Syndrome.挥发性麻醉剂作为急性呼吸窘迫综合征镇静剂的应用
Transl Perioper Pain Med. 2019;6(2):27-38. doi: 10.31480/2330-4871/084. Epub 2019 Feb 21.
5
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa.神经免疫相互作用:从大脑到免疫系统,反之亦然。
Physiol Rev. 2018 Jan 1;98(1):477-504. doi: 10.1152/physrev.00039.2016.
6
Short-Term Regulation of FcR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products.TLRs 对巨噬细胞中 FcR 介导的吞噬作用的短期调控:5-脂氧合酶产物的参与。
Mediators Inflamm. 2017;2017:2086840. doi: 10.1155/2017/2086840. Epub 2017 Aug 15.
7
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.中性粒细胞拯救活性氧:NADPH 氧化酶激活和细菌耐药的机制。
Front Cell Infect Microbiol. 2017 Aug 25;7:373. doi: 10.3389/fcimb.2017.00373. eCollection 2017.
8
Pediatric Perioperative Stress Responses and Anesthesia.小儿围手术期应激反应与麻醉
Transl Perioper Pain Med. 2017;2(1):1-12.
9
From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis.封面文章:长时间暴露于挥发性麻醉剂异氟烷会使多微生物性腹部脓毒症的预后恶化。
Toxicol Sci. 2017 Apr 1;156(2):402-411. doi: 10.1093/toxsci/kfw261.
10
The Hypothalamic-Pituitary-Adrenal Axis and Anesthetics: A Review.下丘脑-垂体-肾上腺轴与麻醉:综述。
Anesth Analg. 2017 Apr;124(4):1181-1189. doi: 10.1213/ANE.0000000000001580.