Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Curr Opin Microbiol. 2020 Dec;58:160-165. doi: 10.1016/j.mib.2020.10.003. Epub 2020 Nov 17.
The innate immune system is critical to proper host defense against fungal pathogens, which is highlighted by increased susceptibility to invasive disease in immunocompromised patients. Innate cells (e.g. macrophages, neutrophils, dendritic cells, eosinophils) are equipped with intricate cell machinery to detect invading fungi and facilitate fungal killing, recruit additional immune cells, and direct the adaptive immune system responses. Understanding the mechanisms that govern a protective response will enable the development of novel treatment strategies. This review focuses on recent insights of signaling and regulation of C-type lectin receptors and their effector mechanisms enabling an effective host antifungal immunity.
先天免疫系统对于宿主防御真菌病原体至关重要，这在免疫功能低下的患者中表现为侵袭性疾病的易感性增加。先天细胞（例如巨噬细胞、中性粒细胞、树突状细胞、嗜酸性粒细胞）配备了复杂的细胞机制来检测入侵的真菌并促进真菌杀伤、招募更多的免疫细胞，并指导适应性免疫系统的反应。了解控制保护性反应的机制将能够开发新的治疗策略。本综述重点介绍了 C 型凝集素受体的信号转导和调节及其效应机制的最新见解，这些机制使宿主具有有效的抗真菌免疫能力。
