Division of Host Defense, Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Division of Host Defense, Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan; Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan; Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan.
Curr Opin Microbiol. 2017 Dec;40:123-130. doi: 10.1016/j.mib.2017.11.004. Epub 2017 Nov 21.
Host immune systems are constantly engaged with fungal pathogens which are common in environments as well as in healthy human skin and mucosa. C-type lectin receptors (CLRs) are expressed in myeloid cells and play central roles in host defenses against fungal infections by coordinating innate and adaptive immune systems. Upon ligand binding, CLRs stimulate cellular responses by inducing the production of cytokines and reactive oxygen species via the Syk/CARD9 signaling pathway, leading to fungal elimination. Due to identification and characterization of the CLRs, the underlying mechanisms of the anti-fungal immunity are being unveiled in the present decade. In this review, we focus on the anti-fungal activities of CLRs and summarize of current knowledge of the related expression profiles, modes of ligand recognition, and signaling cascades.
宿主免疫系统不断与真菌病原体相互作用，而这些真菌病原体在环境中以及健康的人类皮肤和黏膜中很常见。C 型凝集素受体 (CLRs) 在髓系细胞中表达，通过协调先天和适应性免疫系统，在宿主抵御真菌感染中发挥核心作用。在配体结合后，CLRs 通过 Syk/CARD9 信号通路诱导细胞因子和活性氧的产生，从而刺激细胞反应，导致真菌消除。由于 CLRs 的鉴定和表征，在当前十年中，抗真菌免疫的潜在机制正在被揭示。在这篇综述中，我们重点介绍 CLRs 的抗真菌活性，并总结了相关表达谱、配体识别模式和信号级联的最新知识。
