真菌识别与宿主防御机制。
Fungal Recognition and Host Defense Mechanisms.
机构信息
MRC Centre for Medical Mycology, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, United Kingdom.
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605.
出版信息
Microbiol Spectr. 2017 Jul;5(4). doi: 10.1128/microbiolspec.FUNK-0050-2016.
Abstract
Fungi have emerged as premier opportunistic microbes of the 21st century, having a considerable impact on human morbidity and mortality. The huge increase in incidence of these diseases is largely due to the HIV pandemic and use of immunosuppressive therapies, underscoring the importance of the immune system in defense against fungi. This article will address how the mammalian immune system recognizes and mounts a defense against medically relevant fungal species.
摘要
真菌已成为 21 世纪主要的机会性病原体，对人类发病率和死亡率有重大影响。这些疾病发病率的大幅增加在很大程度上归因于 HIV 流行和免疫抑制疗法的应用，这凸显了免疫系统在抵御真菌方面的重要性。本文将探讨哺乳动物免疫系统如何识别和抵御与医学相关的真菌物种。
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