Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.
Department of Microbiology and Immunology, Al-Azhr University, Assiut 11651, Egypt.
Viruses. 2020 Nov 18;12(11):1322. doi: 10.3390/v12111322.
The zinc finger proteins make up a significant part of the proteome and perform a huge variety of functions in the cell. The CCCH-type zinc finger proteins have gained attention due to their unusual ability to interact with RNA and thereby control different steps of RNA metabolism. Since virus infections interfere with RNA metabolism, dynamic changes in the CCCH-type zinc finger proteins and virus replication are expected to happen. In the present review, we will discuss how three CCCH-type zinc finger proteins, ZC3H11A, MKRN1, and U2AF1, interfere with human adenovirus replication. We will summarize the functions of these three cellular proteins and focus on their potential pro- or anti-viral activities during a lytic human adenovirus infection.
锌指蛋白构成了蛋白质组的重要部分，在细胞中发挥着多种多样的功能。由于其与 RNA 相互作用的独特能力，从而控制 RNA 代谢的不同步骤，CCCH 型锌指蛋白引起了人们的关注。由于病毒感染会干扰 RNA 代谢，因此预计 CCCH 型锌指蛋白和病毒复制会发生动态变化。在本综述中，我们将讨论三种 CCCH 型锌指蛋白（ZC3H11A、MKRN1 和 U2AF1）如何干扰人腺病毒的复制。我们将总结这三种细胞蛋白的功能，并重点讨论它们在裂解型人腺病毒感染过程中的潜在促病毒或抗病毒活性。
