Almdahl S M, Bøgwald J, Hoffman J, Seljelid R
Department of Surgery, University Hospital, Tromsø, Norway.
Acta Chir Scand. 1987 Sep;153(9):535-9.
The efficacy of treatment with semisoluble aminated glucan (s.a.g.) and donor peritoneal mononuclear cells was investigated in two separate models of peritonitis (exogenous Escherichia coli challenge or caecal perforation). Intraperitoneal administration of s.a.g. significantly protected against both forms of peritonitis. Our previous studies indicated this protective effect to be mediated by macrophage activation, and this was corroborated by the effect of injecting rats with s.a.g.-stimulated donor peritoneal cells (approximately 95% macrophages) immediately after induction of peritonitis. Increased bacterial clearance and survival time were achieved with this treatment as compared with rats injected with cells from saline-treated donors. Scanning electron microscopy demonstrated activation of macrophages from the s.a.g.-treated rats. The results provided further support for the concept that s.a.g. exerts its therapeutic effect by stimulation of macrophages.
在两种不同的腹膜炎模型（外源性大肠杆菌攻击或盲肠穿孔）中，研究了半溶性胺化葡聚糖（s.a.g.）和供体腹膜单核细胞治疗的效果。腹腔注射s.a.g.可显著预防两种形式的腹膜炎。我们之前的研究表明，这种保护作用是由巨噬细胞激活介导的，在腹膜炎诱导后立即给大鼠注射经s.a.g.刺激的供体腹膜细胞（约95%为巨噬细胞）的效果证实了这一点。与注射来自盐水处理供体的细胞的大鼠相比，这种治疗可提高细菌清除率和延长存活时间。扫描电子显微镜显示了经s.a.g.处理的大鼠巨噬细胞的激活。结果为s.a.g.通过刺激巨噬细胞发挥治疗作用这一概念提供了进一步的支持。
