Almdahl S M, Bøgwald J, Hoffman J, Sjunneskog C, Seljelid R
Scand J Gastroenterol. 1987 Apr;22(3):261-7. doi: 10.3109/00365528709078589.
Rats were subjected to sham laparotomy or splenectomy and were challenged with either 0.2 X 10(9) Escherichia coli intravenously or 1 X 10(9) E. coli intraperitoneally. By means of quantitative blood culturing asplenic animals were shown to have a significantly impaired ability to clear the bacteria in both forms of challenge. Treatment with intraperitoneally injected semisoluble aminated glucan (SAG), known to have strong macrophage-stimulatory properties, compensated completely for the asplenic state. The substance protected against postsplenectomy sepsis both when given before and when given after removal of the spleen. This protective effect of SAG seemed to last at least 3 weeks.
将大鼠进行假剖腹手术或脾切除术，然后分别通过静脉注射0.2×10⁹大肠杆菌或腹腔注射1×10⁹大肠杆菌进行攻击。通过定量血液培养发现，在两种攻击形式下，无脾动物清除细菌的能力均显著受损。腹腔注射已知具有强大巨噬细胞刺激特性的半溶性胺化葡聚糖（SAG）进行治疗，可完全弥补无脾状态。该物质在脾脏切除前或切除后给予均能预防脾切除术后败血症。SAG的这种保护作用似乎至少持续3周。
