LncTarD：一个经实验验证的人类疾病中功能性 lncRNA 靶调控的人工 curated 数据库。
LncTarD: a manually-curated database of experimentally-supported functional lncRNA-target regulations in human diseases.
机构信息
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
College of Bioinformatics, Hainan Medical University, Haikou 570100, China.
出版信息
Nucleic Acids Res. 2020 Jan 8;48(D1):D118-D126. doi: 10.1093/nar/gkz985.
Long non-coding RNAs (lncRNAs) are associated with human diseases. Although lncRNA-disease associations have received significant attention, no online repository is available to collect lncRNA-mediated regulatory mechanisms, key downstream targets, and important biological functions driven by disease-related lncRNAs in human diseases. We thus developed LncTarD (http://biocc.hrbmu.edu.cn/LncTarD/ or http://bio-bigdata.hrbmu.edu.cn/LncTarD), a manually-curated database that provides a comprehensive resource of key lncRNA-target regulations, lncRNA-influenced functions, and lncRNA-mediated regulatory mechanisms in human diseases. LncTarD offers (i) 2822 key lncRNA-target regulations involving 475 lncRNAs and 1039 targets associated with 177 human diseases; (ii) 1613 experimentally-supported functional regulations and 1209 expression associations in human diseases; (iii) important biological functions driven by disease-related lncRNAs in human diseases; (iv) lncRNA-target regulations responsible for drug resistance or sensitivity in human diseases and (v) lncRNA microarray, lncRNA sequence data and transcriptome data of an 11 373 pan-cancer patient cohort from TCGA to help characterize the functional dynamics of these lncRNA-target regulations. LncTarD also provides a user-friendly interface to conveniently browse, search, and download data. LncTarD will be a useful resource platform for the further understanding of functions and molecular mechanisms of lncRNA deregulation in human disease, which will help to identify novel and sensitive biomarkers and therapeutic targets.
长链非编码 RNA（lncRNA）与人类疾病相关。尽管 lncRNA-疾病关联已受到广泛关注，但目前尚无在线数据库可用于收集与人类疾病相关的 lncRNA 介导的调控机制、关键下游靶标和重要生物学功能。因此，我们开发了 LncTarD（http://biocc.hrbmu.edu.cn/LncTarD/或 http://bio-bigdata.hrbmu.edu.cn/LncTarD），这是一个手动整理的数据库，提供了与人类疾病相关的 lncRNA 靶调控、lncRNA 影响的功能和 lncRNA 介导的调控机制的综合资源。LncTarD 提供了（i）2822 个关键的 lncRNA-靶调控，涉及 475 个 lncRNA 和 1039 个与 177 种人类疾病相关的靶标；（ii）1613 个实验支持的功能调控和 1209 个在人类疾病中的表达关联；（iii）人类疾病中由疾病相关 lncRNA 驱动的重要生物学功能；（iv）与人类疾病中的药物耐药性或敏感性相关的 lncRNA-靶调控；以及（v）来自 TCGA 的 11373 个泛癌患者队列的 lncRNA 微阵列、lncRNA 序列数据和转录组数据，以帮助描述这些 lncRNA-靶调控的功能动态。LncTarD 还提供了一个用户友好的界面，方便浏览、搜索和下载数据。LncTarD 将成为进一步理解人类疾病中 lncRNA 失调功能和分子机制的有用资源平台，有助于识别新的和敏感的生物标志物和治疗靶点。
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