School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Academic Neurosurgery Unit, Department of Clinical Neurosurgery, University of Cambridge, Cambridge, UK.
Age Ageing. 2021 May 5;50(3):705-715. doi: 10.1093/ageing/afaa236.
OBJECTIVE: Degenerative cervical myelopathy (DCM) is a disabling neurological condition. The underlying degenerative changes are known to be more common with age, but the impact of age on clinical aspects of DCM has never been synthesised. The objective of this study is to determine whether age is a significant predictor in three domains-clinical presentation, surgical management and post-operative outcomes of DCM. METHODS: a systematic review of the Medline and Embase databases (inception to 12 December 2019), registered with PROSPERO (CRD42019162077) and reported in accordance with preferred reporting items of systematic reviews and meta-analysis (PRISMA) guidelines, was conducted. The inclusion criteria were full text articles in English, evaluating the impact of age on clinical aspects of DCM. RESULTS: the initial search yielded 2,420 citations, of which 206 articles were eventually included. Age was found to be a significant predictor in a variety of measures. Within the presentation domain, older patients have a worse pre-operative functional status. Within the management domain, older patients are more likely to undergo posterior surgery, with more levels decompressed. Within the outcomes domain, older patients have a worse post-operative functional status, but a similar amount of improvement in functional status. Because of heterogenous data reporting, meta-analysis was not possible. CONCLUSION: the current evidence demonstrates that age significantly influences the presentation, management and outcomes of DCM. Although older patients have worse health at all individual timepoints, they experience the same absolute benefit from surgery as younger patients. This finding is of particular relevance when considering the eligibility of older patients for surgery.
目的:退行性颈脊髓病(DCM)是一种使人丧失能力的神经疾病。已知退行性改变随着年龄的增长更为常见,但年龄对 DCM 临床方面的影响从未被综合研究过。本研究的目的是确定年龄是否是 DCM 的临床表现、手术治疗和术后结果的三个领域的重要预测因素。
方法:对 Medline 和 Embase 数据库(从创建到 2019 年 12 月 12 日)进行了系统评价,该评价已在 PROSPERO(CRD42019162077)上注册,并按照系统评价和荟萃分析的首选报告项目(PRISMA)指南进行了报告。纳入标准为评估年龄对 DCM 临床方面影响的英文全文文章。
结果:最初的搜索产生了 2420 条引文,其中最终有 206 篇文章被纳入。研究发现年龄在各种指标上都是一个重要的预测因素。在表现领域,年龄较大的患者术前功能状态较差。在管理领域,年龄较大的患者更有可能接受后路手术,更多的节段减压。在结果领域,年龄较大的患者术后功能状态较差,但功能状态的改善程度相似。由于数据报告存在异质性,因此无法进行荟萃分析。
结论:目前的证据表明,年龄显著影响 DCM 的表现、管理和结果。尽管老年患者在所有个体时间点的健康状况都较差,但他们从手术中获得的绝对益处与年轻患者相同。当考虑老年患者是否适合手术时,这一发现尤其重要。
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