Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R. Iran.
Clinical Research Development Center, Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, I.R. Iran.
Arch Iran Med. 2020 Nov 1;23(11):782-786. doi: 10.34172/aim.2020.104.
The aim of this study was to identify gastrointestinal (GI) and liver injury presentations in children admitted with COVID-19 infection.
In this retrospective study, we studied all children with suspected symptoms of COVID-19, referred to Amirkola Children's Hospital. Clinical manifestations of the digestive and respiratory systems and liver function tests were evaluated for all cases.
Eighteen children were studied. The most common clinical symptoms were fever, anorexia, weakness, nausea and vomiting, cough, diarrhea, and abdominal pain, respectively. Also, 5/18 (27.8%) and 7/18 (38.9%) of cases had abnormally high alanine aminotransferase (ALT), aspartate aminotransferase (AST), respectively. Additionally, in icteric cases, direct bilirubin was raised. There was no significant relationship between pulmonary lesions and abnormal excess in ALT ( = 0.59) and AST ( = 0.62).
The findings showed that there were no severe clinical GI symptoms in children with COVID-19 infection. Besides, children with increased liver enzymes did not have more respiratory involvement than those without a rise in liver enzymes.
本研究旨在确定因 COVID-19 感染而住院的儿童的胃肠道（GI）和肝脏损伤表现。
在这项回顾性研究中，我们研究了所有因疑似 COVID-19 症状而转至阿米尔科拉儿童医院的儿童。对所有病例的消化系统和呼吸系统的临床表现和肝功能检查进行了评估。
研究了 18 名儿童。最常见的临床症状分别为发热、厌食、乏力、恶心和呕吐、咳嗽、腹泻和腹痛。此外，5/18（27.8%）和 7/18（38.9%）的病例的丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）分别异常升高。此外，在黄疸病例中，直接胆红素升高。肺部病变与 ALT（=0.59）和 AST（=0.62）异常升高之间无显著关系。
研究结果表明，COVID-19 感染儿童无严重的胃肠道临床症状。此外，肝酶升高的儿童与肝酶未升高的儿童相比，呼吸道受累情况并无增加。
