Department of Obstetrics and Gynecology, Turku University Central Hospital and University of Turku, Turku, Finland; Department of Obstetrics and Gynecology, Seinäjoki Central Hospital, Seinäjoki, Finland.
Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Food and Nutrition, University of Helsinki, Helsinki, Finland.
Pregnancy Hypertens. 2021 Mar;23:48-55. doi: 10.1016/j.preghy.2020.11.001. Epub 2020 Nov 12.
Considering the burden of preeclampsia (PE), it is important to understand better the underlying risk factors involved in its etiology. We studied the association of background factors with PE with an emphasis on socioeconomic factors, reproductive factors and health history enclosing the parents of pregnant women.
The Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort participants filled in a questionnaire on background information. The questionnaire data was available from 708 women with PE and 724 control women. Two different control groups, healthy controls with uncomplicated pregnancies (n = 498) and all controls (n = 724, including controls with uncomplicated pregnancies and pregnancy complications other than PE), were established.
PE women had similar socioeconomic status and more often non-communicable diseases including type 1 diabetes, chronic hypertension and hyperlipidemia than the two control groups (p < 0.05 for all). Depression and subfertility were more common among PE women and they had earlier menarche (p < 0.05 for all). Hypertension was more common in both parents of PE women, stroke in fathers and diabetes in mothers (p < 0.05 for all). Mental disorders including depression were more common in mothers of PE women compared to controls (PE women 7.2%, healthy controls 3.7% (p = 0.013) and all controls 3.9% (p = 0.007)).
In the FINNPEC cohort, PE women had similar socioeconomic status, more non-communicable diseases and depression, earlier menarche, more subfertility and more parental non-communicable diseases compared to controls. As a novel finding we found more mental disorders including depression in mothers of PE women.
鉴于子痫前期（PE）的负担，了解其病因中涉及的潜在危险因素尤为重要。我们研究了背景因素与 PE 的关联，重点关注社会经济因素、生殖因素和孕妇父母的健康史。
芬兰子痫前期遗传学联合会（FINNPEC）队列参与者填写了一份背景信息问卷。问卷数据可从 708 名 PE 妇女和 724 名对照妇女中获得。建立了两组不同的对照组，一组为无并发症妊娠的健康对照者（n=498），另一组为所有对照者（n=724，包括无并发症妊娠和除 PE 以外的妊娠并发症的对照者）。
PE 妇女的社会经济地位相似，但与两组对照者相比，PE 妇女更常患有非传染性疾病，包括 1 型糖尿病、慢性高血压和高脂血症（p<0.05 均为）。PE 妇女中更常见抑郁和不孕，且初潮较早（p<0.05 均为）。PE 妇女的父母中更常见高血压，父亲中更常见中风，母亲中更常见糖尿病（p<0.05 均为）。与对照组相比，PE 妇女的母亲中更常见精神障碍，包括抑郁（PE 妇女 7.2%，健康对照组 3.7%（p=0.013）和所有对照组 3.9%（p=0.007））。
在 FINNPEC 队列中，与对照组相比，PE 妇女的社会经济地位相似，非传染性疾病、抑郁、初潮更早、不孕和父母的非传染性疾病更多。作为一项新发现，我们发现 PE 妇女的母亲中更常见精神障碍，包括抑郁。
