Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University, Anyang, South Korea.
Department of Biomedical Gerontology, Graduate School of Hallym University, Chuncheon, South Korea; Ilsong Institute of Life Science, Hallym University, Anyang, South Korea.
J Clin Neurosci. 2020 Nov;81:469-476. doi: 10.1016/j.jocn.2020.09.027. Epub 2020 Nov 2.
Self-proliferation of the pathological form of α-synuclein was identified as one of the main pathophysiological presentations of Parkinson's disease (PD) a decade ago. Although inflammation has also been suggested to contribute to PD pathogenesis, it is unclear whether this is associated with the pathological spread of α-synuclein aggregation. Herein, we evaluated two main neuroinflammatory processes in the striatum-microgliosis and astrogliosis-after the injection of preformed fibrils of α-synuclein into the mouse striatum. Thus, our study demonstrated that microgliosis accompanied α-synuclein propagation, while astrogliosis did not. Therefore, we report a preferential association between microglia and the process of α-synuclein proliferation.
十多年前，研究人员发现病理性α-突触核蛋白的自我增殖是帕金森病 (PD) 的主要病理生理学表现之一。尽管炎症也被认为与 PD 的发病机制有关，但尚不清楚这是否与α-突触核蛋白聚集的病理性传播有关。在此，我们评估了将α-突触核蛋白原纤维注射到小鼠纹状体后纹状体中的两种主要神经炎症过程——小胶质细胞激活和星形胶质细胞增生。因此，我们的研究表明小胶质细胞激活伴随着α-突触核蛋白的传播，而星形胶质细胞增生则没有。因此，我们报告了小胶质细胞与α-突触核蛋白增殖过程之间的优先关联。
