叶酸和 VitB 治疗高同型半胱氨酸血症 MCI 患者的效果。

The effect of folate and VitB in the treatment of MCI patients with hyperhomocysteinemia.

机构信息

Department of Neurology, Fourth Medical Center, Chinese PLA General Hospital. Beijing 100048, China.

出版信息

J Clin Neurosci. 2020 Nov;81:65-69. doi: 10.1016/j.jocn.2020.09.043. Epub 2020 Sep 29.

DOI:10.1016/j.jocn.2020.09.043

PMID:33222971

Abstract

OBJECTIVE

This study aims to investigate the effect of folate combined with VitB on serum total homocysteine (tHcy) levels and cognitive function in patients with mild cognitive impairment (MCI) complicated by hyperhomocysteinemia (HHcy).

METHODS

(1) A total of 92 MCI patients with HHcy were enrolled in this study and randomly divided into two groups: the intervention group (46 cases) and the control group (46 cases). (2) The patients in both groups received the routine treatment for their condition, but patients in the intervention group were also given 5 mg/day of folate and 500 μg × 3/day of VitB. (3) The changes in levels of folate, VitB, and tHcy, the Montreal Cognitive Assessment (MoCA) score and the event-related potential (P300) were observed before and after treatment.

RESULTS

(1) There were no statistically significant differences in folate, VitB, and tHcy levels, the MoCA score and the P300 between the two groups before treatment. (2) At the 4th, 12th and 24th week, folate and VitB levels in the intervention group were higher than those in the same group before treatment and those in the control group at the same time points, while tHcy levels were lower than those in the same group before treatment and those in the control group at the same time points. (3) At the 24th week, the MoCA score in the control group was lower than before treatment, and the MoCA score in the intervention group was higher than in the same group before treatment and in the control group at the same time point. The P300 latency was shorter than it was in the same group before treatment and in the control group at the same time point.

CONCLUSION

Folate and VitB can effectively reduce levels of tHcy in patients with MCI and improve cognitive function.

摘要

目的

本研究旨在探讨叶酸联合 VitB 对伴有高同型半胱氨酸血症（HHcy）的轻度认知障碍（MCI）患者血清总同型半胱氨酸（tHcy）水平及认知功能的影响。

方法

（1）纳入 92 例伴有 HHcy 的 MCI 患者，随机分为两组：干预组（46 例）和对照组（46 例）。（2）两组患者均接受常规治疗，干预组患者加用 5mg/d 叶酸和 500μg×3/d VitB。（3）观察治疗前后叶酸、VitB、tHcy 水平、蒙特利尔认知评估量表（MoCA）评分和事件相关电位（P300）的变化。

结果

（1）治疗前两组患者叶酸、VitB、tHcy 水平、MoCA 评分和 P300 无统计学差异。（2）治疗第 4、12、24 周时，干预组叶酸、VitB 水平高于同组治疗前和同期对照组，tHcy 水平低于同组治疗前和同期对照组。（3）治疗第 24 周时，对照组 MoCA 评分低于治疗前，干预组 MoCA 评分高于同组治疗前和同期对照组，P300 潜伏期短于同组治疗前和同期对照组。