Department of Kinesiology and Community Health, College of Applied Health Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, 61820, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
School of Health Studies, Northern Illinois University, DeKalb, IL, USA.
Chemosphere. 2021 Apr;268:128852. doi: 10.1016/j.chemosphere.2020.128852. Epub 2020 Nov 3.
Perfluoroalkyl substances (PFASs) are a class of manmade chemicals commonly used in consumer product manufacturing. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are two of the most highly studied PFASs. Both are present in the blood of the most Americans. PFASs are associated with intermediate cardiovascular disease (CVD) outcomes, but their relationship with obesity, a risk factor for intermediate and advanced CVD, remains largely unconfirmed. In this context, we aimed to explore the relationship between PFASs and both overweight/obesity and abdominal obesity among children.
We examine associations between PFOA and PFOS levels, and Body Mass Index (BMI) and waist circumference (WC) in a representative sample (N = 2473) of US children, aged 12-18 years from the Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey 1999-2012. Overweight/obesity is defined as age-, sex-specific BMI z-score ≥ 85th percentile; abdominal obesity is defined as age-, sex-specific waist circumference ≥90th percentile.
Associations between PFASs and anthropometric outcomes show a dose-response relationship overall. For overweight/obese BMI z-score, findings indicate OR = 1.42 and 95% CI: 0.85-2.38 for quartile 2 of PFOA exposure; OR = 2.22 (95% CI: 1.20-4.13) for quartile 3 of PFOA exposure; and OR = 2.73 (95% CI:1.10-6.74) for quartile 4 of PFOA exposure.
Findings indicate an association between elevated PFOA and overweight/obesity among children after multivariable adjustment.
全氟烷基物质 (PFAS) 是一类常用于消费品制造的人造化学品。全氟辛酸 (PFOA) 和全氟辛烷磺酸 (PFOS) 是研究最多的两种 PFAS。这两种物质都存在于大多数美国人的血液中。PFAS 与中间型心血管疾病 (CVD) 结局有关，但它们与肥胖的关系，肥胖是中间型和晚期 CVD 的一个风险因素，在很大程度上仍未得到证实。在这种情况下，我们旨在探讨 PFAS 与儿童超重/肥胖和腹部肥胖之间的关系。
我们在美国疾病控制与预防中心的全国健康和营养检查调查 1999-2012 年的代表性样本 (N=2473) 中，检查了 PFOA 和 PFOS 水平与儿童 BMI 和腰围 (WC) 之间的关联。超重/肥胖定义为年龄、性别特异性 BMI z 评分≥第 85 百分位数；腹部肥胖定义为年龄、性别特异性腰围≥第 90 百分位数。
PFAS 与人体测量学结果之间的关联总体上呈剂量反应关系。对于超重/肥胖 BMI z 评分，研究结果表明，PFOA 暴露第 2 四分位的比值比 (OR) 为 1.42，95%置信区间 (CI) 为 0.85-2.38；PFOA 暴露第 3 四分位的 OR 为 2.22 (95% CI: 1.20-4.13)；PFOA 暴露第 4 四分位的 OR 为 2.73 (95% CI:1.10-6.74)。
在进行多变量调整后，研究结果表明，PFOA 升高与儿童超重/肥胖之间存在关联。
