Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Community Medicine, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.
Environ Health. 2018 Jan 18;17(1):9. doi: 10.1186/s12940-017-0338-x.
Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies.
Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986-88, and analyses of two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) were conducted. We used linear and logistic regression models with 95% confidence intervals (CIs) to evaluate the associations between maternal serum POP concentrations at 17-20 weeks of gestation and child overweight/obesity (body mass index (BMI) ≥ 85th percentile) at 5-year follow-up. Results were further stratified by country after testing for effect modification. We also assessed potential non-monotonic dose-response (NMDR) relationships.
In adjusted linear models, we observed increased BMI-for-age-and-sex z-score (β = 0.18, 95% CI: 0.01-0.35), and increased triceps skinfold z-score (β = 0.15, 95% CI: 0.02-0.27) in children at 5-year follow-up per ln-unit increase in maternal serum perfluorooctane sulfonate (PFOS) concentrations. We observed increased odds for child overweight/obesity (BMI ≥ 85th percentile) for each ln-unit increase in maternal serum PFOS levels (adjusted OR: 2.04, 95% CI: 1.11-3.74), with stronger odds among Norwegian children (OR: 2.96, 95% CI: 1.42-6.15). We found similar associations between maternal serum perfluorooctanoate (PFOA) concentrations and child overweight/obesity. We found indications of NMDR relationships between PFOS and polychlorinated biphenyl (PCB) 153 and child overweight/obesity among Swedish children.
We found positive associations between maternal serum PFAS concentrations and child overweight/obesity at 5-year follow-up, particularly among Norwegian participants. We observed some evidence for NMDR relationships among Swedish participants.
产前接触持久性有机污染物（POPs）可能会影响后代的体重增长。需要更多的前瞻性流行病学研究来补充动物研究不断增加的证据。
1986-88 年，412 名挪威和瑞典的参与斯堪的纳维亚前瞻性队列研究的孕妇采集血清，并进行两种全氟烷基物质（PFAS）和五种有机氯（OC）的分析。我们使用线性和逻辑回归模型，置信区间（CI）为 95%，评估孕妇妊娠 17-20 周时血清中 POP 浓度与 5 岁时儿童超重/肥胖（体重指数（BMI）≥第 85 百分位数）之间的关系。在检测到效应修饰后，按国家对结果进行分层。我们还评估了潜在的非单调剂量反应（NMDR）关系。
在调整后的线性模型中，我们观察到每增加一个对数单位的母体血清全氟辛烷磺酸（PFOS）浓度，儿童的 BMI 年龄性别 z 分数（β=0.18，95%CI：0.01-0.35）和三头肌皮褶厚度 z 分数（β=0.15，95%CI：0.02-0.27）均增加。我们观察到每增加一个对数单位的母体血清 PFOS 水平，儿童超重/肥胖（BMI≥第 85 百分位数）的几率增加（调整后的 OR：2.04，95%CI：1.11-3.74），挪威儿童的几率更高（OR：2.96，95%CI：1.42-6.15）。我们发现母体血清全氟辛酸（PFOA）浓度与儿童超重/肥胖之间存在类似的关联。我们发现瑞典儿童中 PFOS 和多氯联苯（PCB）153 与儿童超重/肥胖之间存在 NMDR 关系的迹象。
我们发现母体血清 PFAS 浓度与 5 岁时儿童超重/肥胖之间存在正相关关系，尤其是在挪威参与者中。我们在瑞典参与者中观察到一些 NMDR 关系的证据。
