Sandikci Sevinc Can, Colak Seda, Omma Ahmet, Enecik Mehmet E, Ozbalkan Zeynep, Neselioglu Salim, Erel Ozcan
Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Ankara Numune Training and Research Hospital, Ankara, Turkey.
Arch Med Sci. 2019 Jul 18;16(6):1353-1359. doi: 10.5114/aoms.2019.86703. eCollection 2020.
Behçet's disease (BD) is a relapsing systemic inflammatory disorder. The diagnosis of BD is primarily based on clinical findings. Current biomarkers are not yet sufficient to diagnose and cannot anticipate the course of the disease and response to treatment. The aim of this study was to evaluate the relationship between the thiol-disulfide balance and disease activity and organ involvement in BD.
A hundred fifty patients with BD and 100 age- and gender-matched healthy controls were included in the study. Disease activity was assessed with the BD Current Activity form score. Serum levels of native thiol (NT), total thiol (TT), and disulfide were measured and the disulfide/native thiol, disulfide/total thiol and native thiol/total thiol levels were calculated for the patient and control groups.
Native thiol, total thiol, native thiol/total thiol values of the BD patients were significantly lower than those of the control group. The disulfide/native thiol, disulfide/total thiol values of BD patients were higher compared to the control group and the disulfide value of the BD group was slightly higher compared to the control group. No correlation was determined between thiol levels and disease activity and organ involvement in BD.
In patients with Behcet's disease, the thiol-disulfide homeostasis balance shifted towards disulfide formation due to thiol oxidation. It may be used as a novel marker in BD because it is easy, practical, fully automated and relatively inexpensive.
白塞病（BD）是一种复发性全身性炎症性疾病。BD的诊断主要基于临床发现。目前的生物标志物尚不足以用于诊断，也无法预测疾病进程和对治疗的反应。本研究的目的是评估白塞病中硫醇-二硫键平衡与疾病活动及器官受累之间的关系。
本研究纳入了150例白塞病患者和100例年龄及性别匹配的健康对照者。采用白塞病当前活动表评分评估疾病活动度。测定血清中天然硫醇（NT）、总硫醇（TT）和二硫键水平，并计算患者组和对照组的二硫键/天然硫醇、二硫键/总硫醇和天然硫醇/总硫醇水平。
白塞病患者的天然硫醇、总硫醇、天然硫醇/总硫醇值显著低于对照组。白塞病患者的二硫键/天然硫醇、二硫键/总硫醇值高于对照组，且白塞病组的二硫键值略高于对照组。未确定硫醇水平与白塞病疾病活动及器官受累之间的相关性。
在白塞病患者中，由于硫醇氧化，硫醇-二硫键稳态平衡向二硫键形成方向转变。它可能作为白塞病的一种新型标志物，因为它简便、实用、全自动且相对廉价。
