Dervišević Amela, Resić Halima, Sokolović Šekib, Babić Nermina, Avdagić Nesina, Začiragić Asija, Bečiragić Amela, Fajkić Almir, Lepara Orhan, Hadžović-Dzuvo Almira
Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Clinic of Hemodialysis, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Arch Med Sci. 2018 Aug;14(5):1080-1086. doi: 10.5114/aoms.2017.65080. Epub 2017 Jan 13.
Leptin is a cytokine-like hormone which has a complex role in inflammation. However, the importance of leptin in the pathogenesis of rheumatoid arthritis (RA) is far from being fully elucidated. The aim of the study was to determine serum leptin levels in RA patients and to evaluate whether there is an association between disease activity, anthropometric indices and leptin levels.
This hypothesis-generating study included 55 RA patients and 25 matched healthy subjects. The serum leptin concentration was determined by enzyme-linked immunosorbent assay (ELISA).
Median serum leptin level in RA patients of 27.4 ng/ml (14.5-54.9 ng/ml) was statistically significantly higher ( = 0.03) compared with the median leptin value of 16.3 ng/ml (9.6-38.8 ng/ml) determined in healthy controls. The serum leptin level in the high disease activity group was significantly higher ( < 0.0005) than that in the low disease activity group and in healthy controls. A significant difference ( = 0.001) in serum leptin level was also found when the high disease activity group was compared with the moderate disease activity group. In the RA group a statistically significant positive correlation (rho = 0.390; = 0.003) was observed between serum leptin level and disease activity score (DAS28).
The present results show that serum leptin levels are increased and significantly associated with disease activity in patients with RA and may have a valuable role in the inflammatory reactions and pathogenesis of RA.
瘦素是一种细胞因子样激素，在炎症中发挥着复杂的作用。然而，瘦素在类风湿关节炎（RA）发病机制中的重要性尚未完全阐明。本研究的目的是测定RA患者的血清瘦素水平，并评估疾病活动度、人体测量指标与瘦素水平之间是否存在关联。
这项探索性研究纳入了55例RA患者和25例匹配的健康受试者。采用酶联免疫吸附测定法（ELISA）测定血清瘦素浓度。
RA患者的血清瘦素水平中位数为27.4 ng/ml（14.5 - 54.9 ng/ml），与健康对照组测定的中位数16.3 ng/ml（9.6 - 38.8 ng/ml）相比，差异有统计学意义（P = 0.03）。高疾病活动度组的血清瘦素水平显著高于低疾病活动度组和健康对照组（P < 0.0005）。高疾病活动度组与中度疾病活动度组相比，血清瘦素水平也存在显著差异（P = 0.001）。在RA组中，血清瘦素水平与疾病活动评分（DAS28）之间存在统计学意义的正相关（rho = 0.390；P = 0.003）。
目前的结果表明，RA患者的血清瘦素水平升高，且与疾病活动度显著相关，可能在RA的炎症反应和发病机制中发挥重要作用。
