Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine, CF Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Mukoviszidose Institut, Bonn, Germany.
Front Cell Infect Microbiol. 2020 Nov 2;10:601834. doi: 10.3389/fcimb.2020.601834. eCollection 2020.
() frequently colonizes the airways of patients with cystic fibrosis (CF) and can cause severe diseases, such as allergic bronchopulmonary aspergillosis, bronchitis or even pneumonia. However, risk factors, including environmental factors, for acquiring in the respiratory tract of patients with CF are rarely studied and described. The aim of this study was to investigate whether urban or rural life could affect colonization with in the respiratory tract of patients with CF. Due to privacy policy, registry data are usually not linked to patients´ home addresses. It is therefore very difficult to analyze the influence of the patient´s residential environment. This prospective questionnaire survey was carried out in 31 German CF centers in 2018. Only completed surveys, including a clearly assigned type of residential area were included. Statistical analysis was performed by chi-squared test and logistic regression models. A total of 1016 questionnaires were analyzed (Patients` age: 23 ± 13; 0-88 years; female gender: n=492; 48%). The majority of patients with CF live in large cities (n =314; 30.9%) or urban districts (n=461; 45.4%). Prevalence of 30.2% was found for , within the 12 months of investigation period. colonization was significantly associated with urban life (p=0.004). Urban live should be considered as possible new risk factor for colonization with in the respiratory tract of patients with CF. These new results may raise the awareness of the influence of environmental factors on patient outcomes and should be included in patient guidance and preventive measures.
（烟曲霉）常定植于囊性纤维化（CF）患者的气道，可引起严重疾病，如变应性支气管肺曲霉病、支气管炎甚至肺炎。然而，CF 患者呼吸道获得烟曲霉的危险因素，包括环境因素，很少被研究和描述。本研究旨在探讨城市或农村生活是否会影响 CF 患者呼吸道的烟曲霉定植。由于隐私政策，注册数据通常与患者的家庭住址不相关联。因此，分析患者居住环境的影响非常困难。这项前瞻性问卷调查于 2018 年在德国 31 个 CF 中心进行。仅纳入完成的调查问卷，包括明确指定的居住区域类型。采用卡方检验和逻辑回归模型进行统计分析。共分析了 1016 份问卷（患者年龄：23 ± 13；0-88 岁；女性：n=492；48%）。大多数 CF 患者居住在大城市（n=314；30.9%）或市区（n=461；45.4%）。在调查期间的 12 个月内，发现烟曲霉的患病率为 30.2%。烟曲霉定植与城市生活显著相关（p=0.004）。城市生活应被视为 CF 患者呼吸道烟曲霉定植的一个新的可能危险因素。这些新的结果可能会提高人们对环境因素对患者结局影响的认识，并应纳入患者指导和预防措施中。
