Grehn Claudia, Eschenhagen Patience, Temming Svenja, Düesberg Uta, Neumann Konrad, Schwarz Carsten
Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, CF Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Mukoviszidose Institut, Bonn, Germany.
Front Cell Infect Microbiol. 2021 Jan 11;10:601821. doi: 10.3389/fcimb.2020.601821. eCollection 2020.
() frequently colonizes the respiratory tract of patients with cystic fibrosis (CF). is associated with loss of pulmonary function and allergic bronchopulmonary aspergillosis (ABPA), a hypersensitivity fungal lung disease. Environmental factors have impact on CF patients' lung function variation. The aim of this nationwide questionnaire survey was to investigate the amount of CF patients with frequent pet contact including pet species and to examine the potential impact of frequent pet contact on the occurrence of colonization and ABPA diagnosis in these patients. The survey was carried out in 31 German CF centers in 2018. A total of 1232 who completed the surveys were included, and statistical analysis was performed by chi-squared test. Within the study cohort 49.8% of subjects (n = 614; CF patients < 18years: 49.4%, n = 234; ≥ 18years: 50.1%, n = 380) reported frequent contact to pets, of which 60.7% reported frequent contact to dogs, 42.3% to cats and other animals. Of those with frequent pet contact, 71.8% (n = 441) had contact to one pet or more pets from the same family. colonization was not significantly associated with frequent pet contact. ABPA diagnosis was documented in 16.7% (n = 206) of all included CF patients and was significantly associated with frequent pet contact (18.9%, n = 116, p = 0.042), confirming previous single center examinations. Particularly, patients with frequent contact to dogs showed an increased ABPA prevalence of 21.3%. Frequent pet contact might be a risk factor for ABPA. CF patients who are sensitized to should be informed about the increased risk to develop an ABPA by frequent pet contact. Patients with recurrent onset of ABPA should be evaluated in terms of frequent pet contact.
（某菌）常定植于囊性纤维化（CF）患者的呼吸道。它与肺功能丧失及变应性支气管肺曲霉病（ABPA）相关，ABPA是一种超敏性真菌性肺病。环境因素会影响CF患者的肺功能变化。这项全国性问卷调查的目的是调查经常接触宠物的CF患者数量（包括宠物种类），并研究经常接触宠物对这些患者中该菌定植及ABPA诊断发生的潜在影响。该调查于2018年在德国31个CF中心开展。共有1232名完成调查者被纳入，通过卡方检验进行统计分析。在研究队列中，49.8%的受试者（n = 614；＜18岁的CF患者：49.4%，n = 234；≥18岁：50.1%，n = 380）报告经常接触宠物，其中60.7%报告经常接触狗，42.3%报告经常接触猫及其他动物。在那些经常接触宠物的人中，71.8%（n = 441）接触过同一家族的一只或多只宠物。该菌定植与经常接触宠物无显著关联。在所有纳入的CF患者中，16.7%（n = 206）有ABPA诊断记录，且与经常接触宠物显著相关（18.9%，n = 116，p = 0.042），证实了先前的单中心研究结果。特别是，经常接触狗的患者ABPA患病率增加至21.3%。经常接触宠物可能是ABPA的一个危险因素。对该菌致敏的CF患者应被告知因经常接触宠物而患ABPA风险增加。ABPA反复发病的患者应就经常接触宠物情况进行评估。
