Tao Yue, Tao Youhua
Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, P. R. China.
Macromol Rapid Commun. 2021 Mar;42(6):e2000515. doi: 10.1002/marc.202000515. Epub 2020 Nov 23.
Polypeptoids have been prepared and researched for more than 20 years. However, the efficient generation of polypeptoids and sequence-defined polypeptoids faces many challenges and difficulties. The Ugi reaction of amino acids has recently been introduced into polypeptoid chemistry as a new and powerful method to furnish polypeptoids. In the following mini review, the recent progress on the application of the Ugi reaction of amino acids in polypeptoid science, including polypeptoid from sustainable furfural, sequence-defined polypeptoids, and more is summarized. Moreover, the future development of the Ugi reaction of amino acids in polypeptoid science is discussed.
聚肽已被制备和研究了20多年。然而，高效合成聚肽和序列定义的聚肽面临着许多挑战和困难。氨基酸的乌吉反应最近被引入聚肽化学领域，成为一种合成聚肽的新型有效方法。在下面的简短综述中，总结了氨基酸乌吉反应在聚肽科学中的应用进展，包括可持续糠醛来源的聚肽、序列定义的聚肽等。此外，还讨论了氨基酸乌吉反应在聚肽科学中的未来发展。
