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温敏性聚乙二醇化聚氨基酸的最新进展

Recent Advances in Thermoresponsive OEGylated Poly(amino acid)s.

作者信息

Geng Chao, Wang Shixue, Wang Hongda

机构信息

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Jilin 130022, China.

出版信息

Polymers (Basel). 2021 May 31;13(11):1813. doi: 10.3390/polym13111813.

DOI:10.3390/polym13111813
PMID:34072769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8198699/
Abstract

Thermoresponsive polymers have been widely studied in the past decades due to their potential applications in biomedicine, nanotechnology, and so on. As is known, poly(-isopropylacrylamide) (PNIPAM) and poly(oligo(ethylene glycol)methacrylates) (POEGMAs) are the most popular thermoresponsive polymers, and have been studied extensively. However, more advanced thermoresponsive polymers with excellent biocompatibility, biodegradability, and bioactivity also need to be developed for biomedical applications. OEGylated poly(amino acid)s are a kind of novel polymer which are synthesized by attaching one or multiple oligo(ethylene glycol) (OEG) chains to poly(amino acid) (PAA).These polymers combine the great solubility of OEG, and the excellent biocompatibility, biodegradability and well defined secondary structures of PAA. These advantages allow them to have great application prospects in the field of biomedicine. Therefore, the study of OEGylated poly(amino acid)s has attracted more attention recently. In this review, we summarized the development of thermoresponsive OEGylated poly(amino acid)s in recent years, including the synthesis method (such as ring-opening polymerization, post-polymerization modification, and Ugi reaction), stimuli-response behavior study, and secondary structure study. We hope that this periodical summary will be more conducive to design, synthesis and application of OEGylated poly(amino acid)s in the future.

摘要

在过去几十年中，热响应性聚合物因其在生物医学、纳米技术等领域的潜在应用而得到广泛研究。众所周知，聚（N-异丙基丙烯酰胺）（PNIPAM）和聚（甲基丙烯酸寡聚乙二醇酯）（POEGMAs）是最常见的热响应性聚合物，并且已被广泛研究。然而，为了生物医学应用，还需要开发具有优异生物相容性、生物降解性和生物活性的更先进的热响应性聚合物。寡聚乙二醇化聚氨基酸是一类新型聚合物，它是通过将一个或多个寡聚乙二醇（OEG）链连接到聚氨基酸（PAA）上合成的。这些聚合物结合了OEG的良好溶解性以及PAA优异的生物相容性、生物降解性和明确的二级结构。这些优点使其在生物医学领域具有广阔的应用前景。因此，近年来寡聚乙二醇化聚氨基酸的研究受到了更多关注。在这篇综述中，我们总结了近年来热响应性寡聚乙二醇化聚氨基酸的发展情况，包括合成方法（如开环聚合、后聚合修饰和乌吉反应）、刺激响应行为研究和二级结构研究。我们希望这一阶段性总结将更有利于未来寡聚乙二醇化聚氨基酸的设计、合成及应用。

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本文引用的文献

1
Ugi Reaction of Natural Amino Acids: A General Route toward Facile Synthesis of Polypeptoids for Bioapplications.天然氨基酸的乌吉反应：一种用于生物应用的简便合成聚肽模拟物的通用方法。
ACS Macro Lett. 2016 Sep 20;5(9):1049-1054. doi: 10.1021/acsmacrolett.6b00530. Epub 2016 Aug 30.
2
Recent Advances in Stimuli-Responsive Commodity Polymers.刺激响应型商品化聚合物的最新进展
Macromol Rapid Commun. 2021 Sep;42(18):e2100054. doi: 10.1002/marc.202100054. Epub 2021 Mar 22.
3
Ugi Reaction of Amino Acids: From Facile Synthesis of Polypeptoids to Sequence-Defined Macromolecules.
氨基酸的乌吉反应：从多肽类的简便合成到序列定义的大分子
Macromol Rapid Commun. 2021 Mar;42(6):e2000515. doi: 10.1002/marc.202000515. Epub 2020 Nov 23.
4
Recent Advances in Stimuli-Responsive Platforms for Cancer Immunotherapy.刺激响应型肿瘤免疫治疗平台的最新进展
Acc Chem Res. 2020 Oct 20;53(10):2044-2054. doi: 10.1021/acs.accounts.0c00334. Epub 2020 Sep 2.
5
Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity.用于酶活性体内成像的小分子探针的刺激响应原位自组装的最新进展。
Biomater Sci. 2021 Jan 21;9(2):406-421. doi: 10.1039/d0bm00895h. Epub 2020 Jul 6.
6
Peptoids for biomaterials science.用于生物材料科学的类肽。
Biomater Sci. 2014 May 1;2(5):627-633. doi: 10.1039/c3bm60269a. Epub 2014 Jan 16.
7
Polypeptoids synthesis based on Ugi reaction: Advances and perspectives.基于 Ugi 反应的多肽类似物的合成：进展与展望。
Biopolymers. 2019 Jun;110(6):e23288. doi: 10.1002/bip.23288. Epub 2019 May 15.
8
A versatile strategy for the synthesis of sequence-defined peptoids with side-chain and backbone diversity amino acid building blocks.一种用于合成具有侧链和主链多样性氨基酸构建块的序列定义类肽的通用策略。
Chem Sci. 2018 Nov 22;10(5):1531-1538. doi: 10.1039/c8sc03415j. eCollection 2019 Feb 7.
9
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Biomacromolecules. 2019 Apr 8;20(4):1655-1666. doi: 10.1021/acs.biomac.9b00026. Epub 2019 Mar 6.
10
Solution Self-Assemblies of Sequence-Defined Ionic Peptoid Block Copolymers.序列定义的离子型肽段嵌段共聚物的自组装。
J Am Chem Soc. 2018 Mar 21;140(11):4100-4109. doi: 10.1021/jacs.8b00461. Epub 2018 Mar 13.