National Center for Scientific Research "Demokritos", Athens, Greece.
Gen Physiol Biophys. 2020 Nov;39(6):531-544. doi: 10.4149/gpb_2020036.
I recently reported induction of chromatid-type aberrations in human peripheral blood lymphocytes after a single 15 min exposure to universal mobile telecommunications system (UMTS) mobile telephony (MT) electromagnetic field (EMF) from a mobile phone. Lymphocytes from six healthy subjects were stimulated for mitosis, and exposed during the G2/M phase at 1 cm distance from the handset during an active phone call in "talk" mode. The same type of cells from the same subjects treated with a high caffeine dose (~ 290 times above the permissible single dose for an adult human) exhibited the same type of aberrations in a little smaller but comparable degree. The combination of this caffeine dose and the 15 min MT EMF exposure increased dramatically the number of aberrations in all subjects. The combined effect increased almost linearly with increasing duration of exposure to the MT EMF. Thus, MT EMF exposure ~ 136 times below the official limit (ICNIRP 2020) exerts a genotoxic action even greater than that of a caffeine dose ~ 290 times above the corresponding limit. Therefore, with a reasonable approximation, the limit for MT EMFs should be lowered by at least ~ 4 × 104 times (136 × 290) for short-term exposures, and ~ 4 × 106 times for long-term exposures.
我最近报告了在单次 15 分钟接触来自移动电话的通用移动通信系统 (UMTS) 移动电话 (MT) 电磁场 (EMF) 后，人类外周血淋巴细胞中的染色单体型畸变的诱导。来自六位健康受试者的淋巴细胞被刺激进行有丝分裂，并在“通话”模式下处于 G2/M 期时在距离手机 1 厘米处进行暴露。来自同一受试者的相同类型的细胞用高咖啡因剂量（成人允许单次剂量的 290 倍以上）处理，显示出相同类型的较小但可比较程度的畸变。这种咖啡因剂量和 15 分钟 MT EMF 暴露的组合大大增加了所有受试者的畸变数量。随着 MT EMF 暴露时间的增加，联合效应几乎呈线性增加。因此，即使低于官方限制（ICNIRP 2020） 136 倍，MT EMF 暴露也会产生比对应限制高~ 290 倍的咖啡因剂量更大的遗传毒性作用。因此，通过合理近似，对于短期暴露，MT EMF 的限值应至少降低~ 4 × 104 倍（136 × 290），对于长期暴露，应降低~ 4 × 106 倍。
