儿童早期心理社会家庭风险与累积多巴胺敏感评分：与美国 9 岁儿童行为问题的关联。
Early childhood psychosocial family risks and cumulative dopaminergic sensitizing score: Links to behavior problems in U.S. 9-year-olds.
机构信息
Columbia University, Teachers College, National Center for Children and Families (NCCF), Thorndike Hall 525 West 120th Street, Box 39 New York, NY 10027, USA; Tampere University, Faculty of Education and Culture, Main Campus Virta, Åkerlundinkatu 5, P.O. Box 700, FI-33014 Tampere University, Finland; University of Helsinki, Faculty of Educational Sciences, Siltavuorenpenger 5A, P.O. Box 9, 00014 University of Helsinki, Finland.
Columbia University, Teachers College, National Center for Children and Families (NCCF), Thorndike Hall 525 West 120th Street, Box 39 New York, NY 10027, USA; Columbia University, The College of Physicians and Surgeons, New York, NY 10027, USA.
出版信息
J Affect Disord. 2021 Feb 1;280(Pt A):432-441. doi: 10.1016/j.jad.2020.11.026. Epub 2020 Nov 11.
BACKGROUND
We examined, (a) whether in early childhood exposure to risky family environment in different domains (socioeconomic, mental, parenting practices, health behavior, and child-related risks) and accumulatively across various domains (cumulative risk) is associated with child's problem behavior at age 9, and (b) whether the association is more pronounced in children carrying cumulative dopaminergic sensitizing genotype or living in low-income families.
METHODS
Participants were 2,860 9-year old children (48% females; 48% Black) and their mothers from the 'Fragile Families and Child Wellbeing Study', a probability birth cohort from large U.S. cities. Mothers responded to questions on child's problem behavior (CBCL). Children responded to questions about their vandalism and substance use.
RESULTS
Cumulative family risk was associated with higher internalizing and externalizing behavior and higher vandalism and substance use. All domain-specific risk clusters were associated with higher internalizing behavior and, with the exception of child-related risk, with higher externalizing behavior. Mental health risks, risky parenting practices, and risky health behavior were associated with higher vandalism. Risky parenting practices were associated with higher substance use. The associations were robust to adjustment for cumulative dopaminergic sensitizing genotype. No G x E interactions with dopaminergic genotype and family SES were observed.
LIMITATIONS
Sample size was relatively small for genetic analysis and polygenic risk scores were not available.
CONCLUSIONS
Exposure to cumulative psychosocial family risks from early childhood is associated with early indicators of problem behavior in adolescence.
背景
我们研究了(a)在不同领域（社会经济、心理、育儿实践、健康行为和儿童相关风险）和跨多个领域（累积风险）中，儿童早期接触风险家庭环境是否与 9 岁时的行为问题有关，以及(b)在携带累积多巴胺敏感基因型或生活在低收入家庭的儿童中，这种关联是否更为明显。
方法
参与者为来自“脆弱家庭与儿童健康研究”的 2860 名 9 岁儿童（48%为女性；48%为黑人）及其母亲。母亲们回答了有关儿童行为问题（CBCL）的问题。孩子们回答了关于他们破坏行为和物质使用的问题。
结果
累积家庭风险与更高的内化和外化行为以及更高的破坏行为和物质使用有关。所有特定领域的风险集群都与更高的内化行为有关，除了儿童相关风险外，还与更高的外化行为有关。心理健康风险、不良育儿实践和危险的健康行为与更高的破坏行为有关。不良育儿实践与更高的物质使用有关。在调整累积多巴胺敏感基因型后，这些关联仍然存在。未观察到多巴胺能基因型和家庭 SES 与 G×E 相互作用。
局限性
遗传分析的样本量相对较小，并且没有多基因风险评分。
结论
儿童早期接触累积的心理社会家庭风险与青春期早期的行为问题早期指标有关。
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