Department of Experimental, Diagnostic and Specialty Medicine Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Center for Applied Biomedical Research (CRBA), Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Cells. 2020 Nov 19;9(11):2503. doi: 10.3390/cells9112503.
Eukaryotic cytoplasmic ribosomes are highly structured macromolecular complexes made up of four different ribosomal RNAs (rRNAs) and 80 ribosomal proteins (RPs), which play a central role in the decoding of genetic code for the synthesis of new proteins. Over the past 25 years, studies on yeast and human models have made it possible to identify (ribosomal protein L10 gene), which is a constituent of the large subunit of the ribosome, as an important player in the final stages of ribosome biogenesis and in ribosome function. Here, we reviewed the literature to give an overview of the role of RPL10 in physiologic and pathologic processes, including inherited disease and cancer.
真核细胞质核糖体是高度结构化的大分子复合物，由四个不同的核糖体 RNA(rRNA)和 80 个核糖体蛋白(RP)组成，在解码遗传密码以合成新蛋白质方面发挥着核心作用。在过去的 25 年中，对酵母和人类模型的研究使得人们能够鉴定出核糖体大亚基的组成部分核糖体蛋白 L10 基因，作为核糖体生物发生和核糖体功能的最后阶段的重要参与者。在这里，我们回顾了文献，概述了 RPL10 在生理和病理过程中的作用，包括遗传性疾病和癌症。
