Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada.
Department of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Int J Environ Res Public Health. 2020 Nov 19;17(22):8591. doi: 10.3390/ijerph17228591.
We compared cognitive profiles in chronic heart failure patients (HF), heart transplant recipients (HT) and healthy controls (HC) and examined the relationship between cardiorespiratory fitness (V˙O), peak cardiac output (CO) and cognitive performance. Stable HT patients ( = 11), HF patients ( = 11) and HC ( = 13) (61.5 ± 8.5 years) were recruited. Four cognitive composite scores targeting different cognitive functions were computed from neuropsychological tests: working memory, processing speed, executive functions and verbal memory. Processing speed and executive function scores were higher, which indicates lower performances in HF and HT compared to HC ( < 0.05). V˙O and first ventilatory threshold (VT) were lower in HF and HT vs. HC ( < 0.01). CO was lower in HF vs. HT and HC ( < 0.01). Processing speed, executive function and verbal memory performances were correlated with V˙O, VT and peak cardiac hemodynamics ( < 0.05). Mediation analyses showed that V˙O and VT mediated the relationship between group and processing speed and executive function performances in HF and HT. CO fully mediated executive function and processing speed performances in HF only. V˙O and CO were related to cognitive performance in the entire sample. In addition, V˙O and VT fully mediated the relationship between group and executive function and processing speed performances.
我们比较了慢性心力衰竭患者（HF）、心脏移植受者（HT）和健康对照者（HC）的认知特征，并探讨了心肺功能（V˙O）、峰值心输出量（CO）与认知表现之间的关系。纳入稳定的 HT 患者（n = 11）、HF 患者（n = 11）和 HC（n = 13）（61.5 ± 8.5 岁）。通过神经心理学测试计算了四个针对不同认知功能的认知综合评分：工作记忆、处理速度、执行功能和言语记忆。处理速度和执行功能评分较高，表明 HF 和 HT 患者的认知表现低于 HC（<0.05）。HF 和 HT 患者的 V˙O 和第一通气阈值（VT）均低于 HC（<0.01）。HF 患者的 CO 低于 HT 和 HC（<0.01）。处理速度、执行功能和言语记忆表现与 V˙O、VT 和峰值心脏血液动力学相关（<0.05）。中介分析表明，V˙O 和 VT 介导了 HF 和 HT 组间与处理速度和执行功能表现之间的关系。仅在 HF 中，CO 完全介导了执行功能和处理速度表现。V˙O 和 CO 与整个样本的认知表现相关。此外，V˙O 和 VT 完全介导了组间与执行功能和处理速度表现之间的关系。
