School of Chemical Engineering and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Korea.
School of Materials Science and Engineering, Nanyang Technological University, Singapore 637553, Singapore.
Molecules. 2020 Nov 19;25(22):5414. doi: 10.3390/molecules25225414.
oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially quassinoids, and in exploring how they can be incorporated into nanomedicine delivery strategies for improved application prospects. Herein, we cover the latest progress in developing different classes of drug delivery vehicles, including nanoemulsions, liposomes, nanostructured lipid carriers, and spongosomes, to encapsulate BJO and purified quassinoids. An introduction to the composition and medicinal activities of BJO and its molecular components, including quassinoids and fatty acids, is first provided. Application examples involving each type of drug delivery vehicle are then critically presented. Future opportunities for nanomedicine delivery strategies in the field are also discussed and considered within the context of translational medicine needs and drug development processes.
莪术油（BJO）在中医药中被广泛用于治疗各种类型的癌症和炎症性疾病。人们对 BJO 及其分子成分（特别是双环二萜类化合物）的药用活性很感兴趣，并探讨如何将其纳入纳米医学递药策略，以提高应用前景。本文综述了开发不同类型药物载体（包括纳米乳剂、脂质体、纳米结构脂质载体和海绵体）以包封 BJO 和纯化双环二萜类化合物的最新进展。首先介绍了 BJO 及其分子成分（包括双环二萜类化合物和脂肪酸）的组成和药用活性。然后批判性地介绍了每种类型药物载体的应用实例。还根据转化医学需求和药物开发过程，讨论并考虑了纳米医学递药策略在该领域的未来机遇。
