State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR.
Gut Microbes. 2021 Jan-Dec;13(1):1847629. doi: 10.1080/19490976.2020.1847629. Epub 2020 Nov 24.
Colorectal cancer (CRC) ranks the third most common cancer type in both men and women. Besides the known genetic and epigenetic changes in the gut epithelial cells, we now know that disturbed gut microbes could also contribute to the onset and progression of CRC. Hence, keeping a balanced gut microbiota (GM) has become a novel pursue in the medical field, particularly in the area of gastrointestinal disorders. (Gp) is a dietary herbal medicine. In our previous study, Gp saponins (GpS) displayed prebiotic and cancer-preventive properties through the modulation of GM in Apc mice. However, the specific group(s) of GM links to the health effects of GpS remains unknown. To track down the missing link, we first investigated and found that inoculation with fecal materials from GpS-treated Apc mice effectively reduces polyps in Apc mice. From the same source of the fecal sample, we successfully isolated 16 bacterial species. Out of the 16 bacteria, stands out as the responder to the GpS-growth stimulus. Biochemical and RNAseq analysis demonstrated that GpS enhanced expressions of a wide range of genes encoding biogenesis and metabolic pathways in culture. Moreover, we found that colonization of markedly reduces the polyp burden in Apc mice. These findings reveal a mutualistic interaction between the prebiotic and a probiotic to achieve anticancer and cancer-preventive activities. Our result, for the first time, unveils the anticancer function of and extend the probiotic horizon of .
结直肠癌（CRC）在男性和女性中均排名第三常见的癌症类型。除了肠道上皮细胞中已知的遗传和表观遗传变化外，我们现在知道肠道微生物的紊乱也可能导致 CRC 的发生和发展。因此，保持肠道微生物群的平衡已成为医学领域的一个新追求，特别是在胃肠道疾病领域。（Gp）是一种膳食草药。在我们之前的研究中，Gp 皂苷（GpS）通过调节 Apc 小鼠中的 GM 显示出了益生元和预防癌症的特性。然而，与 GpS 健康效应相关的确切 GM 群体尚不清楚。为了找到缺失的环节，我们首先进行了调查，发现接种 GpS 处理的 Apc 小鼠的粪便材料可有效减少 Apc 小鼠的息肉。从相同来源的粪便样本中，我们成功分离出 16 种细菌。在这 16 种细菌中，是对 GpS 生长刺激的响应者。生化和 RNAseq 分析表明，GpS 增强了 培养物中广泛编码生物发生和代谢途径的基因的表达。此外，我们发现 定植可显著减少 Apc 小鼠的息肉负担。这些发现揭示了益生元和益生菌之间的互利相互作用，以实现抗癌和预防癌症的活性。我们的结果首次揭示了 的抗癌功能，并扩展了 的益生菌范围。
