Kim Donghyun, Zeng Melody Y, Núñez Gabriel
Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea.
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Exp Mol Med. 2017 May 26;49(5):e339. doi: 10.1038/emm.2017.24.
Many benefits provided by the gut microbiota to the host rely on its intricate interactions with host cells. Perturbations of the gut microbiota, termed gut dysbiosis, affect the interplay between the gut microbiota and host cells, resulting in dysregulation of inflammation that contributes to the pathogenesis of chronic inflammatory diseases, including inflammatory bowel disease, multiple sclerosis, allergic asthma and rheumatoid arthritis. In this review, we provide an overview of how gut bacteria modulates host metabolic and immune functions, summarize studies that examined the roles of gut dysbiosis in chronic inflammatory diseases, and finally discuss measures to correct gut dysbiosis as potential therapeutics for chronic inflammatory diseases.
肠道微生物群为宿主提供的许多益处依赖于其与宿主细胞的复杂相互作用。肠道微生物群的扰动，即肠道生态失调，会影响肠道微生物群与宿主细胞之间的相互作用，导致炎症调节异常，进而促成包括炎症性肠病、多发性硬化症、过敏性哮喘和类风湿性关节炎在内的慢性炎症性疾病的发病机制。在这篇综述中，我们概述了肠道细菌如何调节宿主代谢和免疫功能，总结了研究肠道生态失调在慢性炎症性疾病中作用的研究，最后讨论了纠正肠道生态失调作为慢性炎症性疾病潜在治疗方法的措施。
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