Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Medical Research Council - Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.
Clin Epigenetics. 2020 Nov 23;12(1):182. doi: 10.1186/s13148-020-00976-5.
Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the nuclear DNA. As such, variations in nuclear gene expression as a consequence of mutations and epigenetic modifications can affect mitochondrial functionality. Conversely, the opposite could also be true. However, the relationship between mitochondrial dysfunction and epigenetics, such as nuclear DNA methylation, remains largely unexplored. Mitochondria function as central metabolic hubs controlling some of the main substrates involved in nuclear DNA methylation, via the one carbon metabolism, the tricarboxylic acid cycle and the methionine pathway. Here, we review key findings and highlight new areas of focus, with the ultimate goal of getting one step closer to understanding the genomic effects of mitochondrial dysfunction on nuclear epigenetic landscapes.
线粒体 DNA 和核 DNA。因此，核基因突变和表观遗传修饰导致的核基因表达变化可能会影响线粒体功能。相反，情况也可能如此。然而，线粒体功能障碍与表观遗传之间的关系，如核 DNA 甲基化，在很大程度上仍未得到探索。线粒体作为中央代谢枢纽，通过一碳代谢、三羧酸循环和蛋氨酸途径，控制着一些参与核 DNA 甲基化的主要底物，发挥着重要作用。在这里，我们回顾了关键发现，并强调了新的关注领域，最终目标是更深入地了解线粒体功能障碍对核表观遗传景观的基因组影响。
