Department of Psychology, The Chinese University of Hong Kong, Hong Kong SAR.
Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR.
J Affect Disord. 2021 Feb 15;281:949-957. doi: 10.1016/j.jad.2020.11.019. Epub 2020 Nov 18.
Life Goals Programme (LGP) was developed as a psychological intervention for bipolar disorder, with its structured 6-session psychoeducation phase (Phase 1) targeting understanding of the disorder, medication adherence, early warning signs, and coping with symptoms and triggers. The present study tested the efficacy of Phase 1 of the LGP on symptom recovery and moment-by-moment mood stability, as well as medication adherence and quality of life.
Adults with bipolar disorder were randomly allocated to the LGP condition (six weekly group sessions) or the waitlist condition (six weeks of standard care, followed by the same LGP intervention). Participants were assessed before and after treatment, and at 6-month follow up. Waitlist participants were additionally assessed at baseline. Assessment included a clinical interview (SCID, MADRS, YMRS, and HAM-A), self-reported questionnaires, and 6-day experience sampling assessment on a mobile device.
64 out-patients with bipolar disorder (44 Bipolar I and 20 Bipolar II subtypes) participated in this study. LGP was well received and attended. Following LGP, there were significant improvements in knowledge about illness and level of anxiety, which were of large effect sizes and sustained at 6-month follow-up. Experience sampling assessment revealed small but significant improvements in moment-by-moment mood stability. Improvement in medication adherence was significant at 6 months and was of a moderate-to-large effect size. Changes in anxiety and mood stability were significantly greater following LGP than standard care.
Our results warrant further testing against active control.
There was a robust improvement in emotional regulation following the 6-week LGP.
生活目标计划（LGP）是作为一种针对双相情感障碍的心理干预措施而开发的，其包含 6 个疗程的结构化心理教育阶段（第 1 阶段），旨在帮助患者理解疾病、遵医嘱服药、识别早期预警信号、以及应对症状和触发因素。本研究旨在测试 LGP 第 1 阶段在症状恢复和情绪稳定性、遵医嘱服药情况和生活质量方面的疗效。
将成年双相情感障碍患者随机分配到 LGP 组（每周六次小组课程）或候补组（六周标准护理，随后进行相同的 LGP 干预）。参与者在治疗前、治疗后和 6 个月随访时进行评估。候补组参与者在基线时也进行了评估。评估包括临床访谈（SCID、MADRS、YMRS 和 HAM-A）、自我报告问卷和移动设备上的 6 天体验抽样评估。
本研究共纳入 64 名门诊双相情感障碍患者（44 名双相 I 型和 20 名双相 II 型）。LGP 组受到了患者的欢迎，参与度高。在 LGP 之后，患者对疾病的认识和焦虑程度都有显著改善，且效果显著，并在 6 个月随访时得以维持。体验抽样评估显示，情绪稳定性在瞬间有较小但显著的改善。遵医嘱服药的改善在 6 个月时显著，且具有中到大的效果量。与标准护理相比，LGP 后焦虑和情绪稳定性的改善更为显著。
我们的结果需要进一步与活性对照进行检验。
在接受 6 周的 LGP 后，情绪调节能力得到了显著改善。
