Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Bünteweg 9, D-30559 Hannover, Germany.
Res Vet Sci. 2021 Mar;135:253-259. doi: 10.1016/j.rvsc.2020.09.015. Epub 2020 Sep 18.
The aim of this study was to assess the "FreeStyle Libre" flash glucose monitoring system regarding its measurement accuracy and tolerability in cats. Results from 66 sensors applied to 34 predominantly diabetic cats are included. The behaviour during the attachment, wearing, and removal of the sensor and the skin site of attachment were assessed. Blood samples were regularly collected for comparative measurements (hexokinase method). Minimal signs of discomfort were noted, although the sensor was additionally fixed using individual skin stitches. Sensors, which stopped working in situ (70% [46/66]), had a median functional life of 8.3 (1.6-14) days. Skin reactions on the adhesive surface occurred after removal of 39% (23) of 59 sensors with assessable skin reaction (mild erythema: n = 21; superficial dermatitis: n = 2). Due to the upper limit of the measurement range of 27.8 mmol/l (500 mg/dl), the reading device displayed "Hi" in 62% (17/34) of cats repeatedly and/or for periods >1 h. Results were highly correlated with those of the reference method (r = 0.90, n = 359). 67.7% (243/359) of the "FreeStyle Libre" measurement values had a maximum deviation of 15% from reference measurements and 99.4% (357/359) were within the zones A and B of Parkes Consensus error grid analysis. In conclusion, the device proved to be practicable, less stressful for the animals and generated in general acceptable results. Although the upper limit of the measurement range is a limiting factor, the device promises to significantly facilitate the management of diabetic cats.
本研究旨在评估“FreeStyle Libre”瞬态葡萄糖监测系统在猫中的测量准确性和耐受性。共纳入 34 只主要患有糖尿病的猫的 66 个传感器的结果。评估了传感器的附着、佩戴和移除期间的行为以及附着的皮肤部位。定期采集血样进行比较测量（己糖激酶法）。尽管传感器还使用单独的皮肤缝线进行了固定，但仅观察到轻微的不适迹象。有 70%（46/66）的传感器在原位停止工作，其中位功能寿命为 8.3（1.6-14）天。在可评估皮肤反应的 59 个传感器中，有 39%（23）在移除后出现皮肤反应（轻度红斑：n=21；浅表性皮炎：n=2）。由于测量范围上限为 27.8mmol/l（500mg/dl），读数设备在 62%（17/34）的猫中反复且/或持续>1 小时显示“Hi”。结果与参考方法高度相关（r=0.90，n=359）。在 359 个“FreeStyle Libre”测量值中，有 67.7%（243）的测量值与参考测量值的最大偏差为 15%，99.4%（357）的测量值在 Parkes 共识误差网格分析的 A 和 B 区。总之，该设备被证明是可行的，对动物的压力较小，并且总体上产生了可接受的结果。尽管测量范围上限是一个限制因素，但该设备有望极大地简化糖尿病猫的管理。
