HIV-1 感染肾脏：机制与意义。
HIV-1 infection of the kidney: mechanisms and implications.
机构信息
Division of Infectious Diseases, Department of Medicine.
Duke Human Vaccine Institute.
出版信息
AIDS. 2021 Mar 1;35(3):359-367. doi: 10.1097/QAD.0000000000002753.
Abstract
People living with HIV are at higher risk for acute and chronic kidney disease compared with uninfected individuals. Kidney disease in this population is multifactorial, with several contributors including HIV infection of kidney cells, chronic inflammation, genetic predisposition, aging, comorbidities, and coinfections. In this review, we provide a summary of recent advancements in the understanding of the mechanisms and implications of HIV infection and kidney disease, with particular focus on the role of direct HIV infection of renal cells.
摘要
与未感染人群相比，HIV 感染者发生急性和慢性肾脏病的风险更高。该人群的肾脏病是多因素的，包括 HIV 感染肾脏细胞、慢性炎症、遗传易感性、衰老、合并症和合并感染。在这篇综述中，我们总结了 HIV 感染和肾脏病发病机制及影响的最新研究进展，重点介绍了 HIV 对肾脏细胞的直接感染作用。
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