Wyatt Christina M
Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Top Antivir Med. 2017 Feb/Mar;25(1):13-16.
The risk of acute and chronic kidney disease remains higher in HIV-infected persons than in the general population, and kidney disease in HIV-infected persons is associated with poor outcomes, including increased mortality. HIV-associated nephropathy occurs less frequently in the era of antiretroviral therapy. HIV immune complex kidney disease is being diagnosed more frequently, but the term is currently used to refer to a heterogeneous group of kidney diseases. Comorbid chronic kidney disease poses a growing burden in HIV-infected persons due to an overrepresentation of risk factors such as black race, diabetes, hypertension, and coinfection with hepatitis C virus. Drug-induced kidney toxicity also remains a concern. This article summarizes a presentation by Christina M. Wyatt, MD, at the Ryan White HIV/AIDS Program Clinical Care Conference held in New Orleans, Louisiana, in December 2015.
与普通人群相比，HIV感染者发生急慢性肾病的风险仍然更高，且HIV感染者的肾病与不良预后相关，包括死亡率增加。在抗逆转录病毒治疗时代，HIV相关性肾病的发生率较低。HIV免疫复合物肾病的诊断越来越频繁，但该术语目前用于指代一组异质性肾病。由于黑人种族、糖尿病、高血压以及丙型肝炎病毒合并感染等风险因素的过度存在，合并慢性肾病给HIV感染者带来了日益沉重的负担。药物性肾毒性也仍然是一个问题。本文总结了医学博士克里斯蒂娜·M·怀亚特于2015年12月在路易斯安那州新奥尔良市举行的瑞安·怀特HIV/AIDS项目临床护理会议上的一次演讲。
