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ART 和血清白蛋白是影响 HIV 维持性血液透析患者 5 年生存率的因素:一项队列研究。

ART and Serum albumin are influencing factors of the 5-year survival rate of people living with HIV undergoing maintenance hemodialysis caused by HIV: A cohort study.

机构信息

Department of Blood Purification, the Fourth People's Hospital of Nanning, Guangxi (Guangxi AIDS Clinical Treatment Center), Nanning, China.

Department of Traditional Chinese Medicine, the Fourth People's Hospital of Nanning, Guangxi (Guangxi AIDS Clinical Treatment Center), Nanning, China.

出版信息

Medicine (Baltimore). 2023 Oct 6;102(40):e35494. doi: 10.1097/MD.0000000000035494.

Abstract

Human immunodeficiency virus (HIV) infection is one of the most prominent public health problems worldwide. The 5-year survival rate of people living with HIV undergoing maintenance hemodialysis (MHD) and the factors related to the survival rate have not been widely studied. This study calculated the 5-year survival rate of people living with HIV who were undergoing MHD and determined the risk factors that may affect the 5-year survival rate. All enrolled participants were followed up for more than 5 years from the first round of MHD. The survival rate of them was calculated, the Cox proportional hazards model was used for multivariate analysis, the Kaplan-Meier method was used to draw the survival curve, and the log-rank test was used to compare the survival time of different groups. A total of 121 participants were included in the study. Statistical analysis showed that the overall 5-year survival rate was 19.0%. The 6-, 12-, 24-, and 36-month survival rates were 71.90%, 56.20%, 41.32%, and 30.58%, respectively. Infection was the leading cause of death, accounting for 55.37%. The Cox proportional hazards model revealed that antiretroviral therapy (ART) and the serum albumin level after dialysis were independent protective factors for patient survival. The log-rank test showed that there was a significant difference in survival time between the ART and non-ART groups.

摘要

人类免疫缺陷病毒(HIV)感染是全球最突出的公共卫生问题之一。接受维持性血液透析(MHD)的 HIV 感染者的 5 年生存率及其生存率相关因素尚未得到广泛研究。本研究计算了接受 MHD 的 HIV 感染者的 5 年生存率,并确定了可能影响 5 年生存率的危险因素。所有入组患者均从首次 MHD 开始进行了超过 5 年的随访。计算了他们的生存率,使用 Cox 比例风险模型进行多变量分析,使用 Kaplan-Meier 方法绘制生存曲线,使用对数秩检验比较不同组的生存时间。共有 121 名患者纳入研究。统计分析显示,总体 5 年生存率为 19.0%。6、12、24 和 36 个月的生存率分别为 71.90%、56.20%、41.32%和 30.58%。感染是导致死亡的主要原因,占 55.37%。Cox 比例风险模型显示,抗逆转录病毒治疗(ART)和透析后血清白蛋白水平是患者生存的独立保护因素。对数秩检验显示,ART 组和非 ART 组的生存时间有显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d427/10553035/99f705df7a03/medi-102-e35494-g001.jpg

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