Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, China.
Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
J Sci Food Agric. 2021 Jun;101(8):3366-3375. doi: 10.1002/jsfa.10966. Epub 2020 Dec 13.
As an edible and medicinal herb in Chinese folk medicine, Cyclocarya paliurus (Batal.) Iljinskaja leaves are traditionally widely used in the treatment of metabolic disorders. The vegetable Momordica charantia L. has been consumed worldwide for thousands of years as a traditional drug due to its activities against obesity and diabetes. In view of the therapeutic value of Momordica saponins (MSs) and C. paliurus polysaccharides (CPPs), an independently developed MSs- and CPPs-containing beverage (MC) was evaluated for its efficacy in controlling oxidative stress and obesity in Caenorhabditis elegans.
First, we found that MC could promote the nuclear localization of DAF-16 and the translation of SOD-3. Further exploring its antioxidant properties, the oxidative stress by-products reactive oxygen species, malondialdehyde, and nonesterified fatty acids were significantly inhibited in C. elegans. Moreover, damage due to diseases related to oxidative stress (age pigments and neurodegenerative diseases) was alleviated. Furthermore, fat accumulation was significantly reduced in normal and high-fat models. Finally, the lipid-lowering effects of MC might involve reductions in the size and number of lipid droplets without impairing basic physiological functions in C. elegans.
These results provide promising data indicating MC as an innovative health beverage for the pharmacological management of oxidative stress and obesity. © 2020 Society of Chemical Industry.
青钱柳叶作为中国民间医学中的一种食用和药用草药，传统上广泛用于治疗代谢紊乱。苦瓜作为一种传统药物，因其具有抗肥胖和糖尿病的作用，在全世界被食用了数千年。鉴于苦瓜皂甙 (MSs) 和青钱柳多糖 (CPPs) 的治疗价值，我们开发了一种含有 MSs 和 CPPs 的自主研发饮料 (MC)，并评估其在控制秀丽隐杆线虫氧化应激和肥胖方面的功效。
首先，我们发现 MC 可以促进 DAF-16 的核定位和 SOD-3 的翻译。进一步探索其抗氧化特性，MC 可显著抑制秀丽隐杆线虫中的氧化应激副产物活性氧、丙二醛和非酯化脂肪酸。此外，还减轻了与氧化应激相关疾病（年龄色素和神经退行性疾病）造成的损伤。此外，MC 还可显著减少正常和高脂肪模型中的脂肪堆积。最后，MC 的降脂作用可能涉及减少脂滴的大小和数量，而不会损害秀丽隐杆线虫的基本生理功能。
这些结果提供了有前景的数据，表明 MC 是一种创新的健康饮料，可用于药物治疗氧化应激和肥胖。 © 2020 英国化学学会。
