新型4-喹诺酮类药物对SOS反应的诱导作用。
Induction of the SOS response by new 4-quinolones.
作者信息
Phillips I, Culebras E, Moreno F, Baquero F
机构信息
Department of Microbiology, Hospital Ramon y Cajal, Madrid, Spain.
出版信息
J Antimicrob Chemother. 1987 Nov;20(5):631-8. doi: 10.1093/jac/20.5.631.
The 4-quinolones ciprofloxacin, difloxacin, enoxacin, norfloxacin, ofloxacin, and nalidixic acid were found to induce the SOS response in qualitative and quantitative tests on Escherichia coli K12 containing the sfiA::lacZ gene fusion. Maximum induction of the SOS-response was observed with the quinolone concentrations that produced the most killing. There was also a modest increase in the rate of mutation in the lactose and galactose operons in a GalE- background, provided there was a functioning SOS system.
在对含有sfiA::lacZ基因融合的大肠杆菌K12进行的定性和定量测试中，发现4-喹诺酮类药物环丙沙星、双氟沙星、依诺沙星、诺氟沙星、氧氟沙星和萘啶酸可诱导SOS反应。在产生最大杀菌效果的喹诺酮浓度下，观察到SOS反应的最大诱导。在GalE背景下，只要存在起作用的SOS系统，乳糖和半乳糖操纵子中的突变率也会适度增加。
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