Majtánová L, Majtán V
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Folia Microbiol (Praha). 1996;41(3):233-6. doi: 10.1007/BF02814622.
The genotoxicity of quinolone antibiotics (ciprofloxacin, enoxacin, nalidixic acid, norfloxacin, ofloxacin, pefloxacin) was studied on the selected mutant E. coli strain PQ 37 (SOS chromotest). The genotoxicity was expressed by SOS-inducing potential (SOSIP) values. The highest SOSIP values were found with ciprofloxacin (SOSIP = 1967 delta IF/nmol), the lowest value was observed with nalidixic acid (SOSIP = 0.3 delta IF/nmol). Similar results were also found with the biosynthesis of nucleic acids, as indicated by incorporation of 14C-adenine into TCA-insoluble fractions of S. typhimurium cells (ciprofloxacin IC50 = 0.39, nalidixic acid IC50 = 400). DNA-damaging effects were tested in the absence of an exogenous metabolizing system.
在选定的突变型大肠杆菌菌株PQ 37（SOS色变试验）上研究了喹诺酮类抗生素（环丙沙星、依诺沙星、萘啶酸、诺氟沙星、氧氟沙星、培氟沙星）的遗传毒性。遗传毒性通过SOS诱导潜力（SOSIP）值来表示。环丙沙星的SOSIP值最高（SOSIP = 1967 δIF/nmol），萘啶酸的SOSIP值最低（SOSIP = 0.3 δIF/nmol）。14C-腺嘌呤掺入鼠伤寒沙门氏菌细胞的三氯乙酸不溶性部分表明，在核酸生物合成方面也发现了类似结果（环丙沙星IC50 = 0.39，萘啶酸IC50 = 400）。在没有外源代谢系统的情况下测试了DNA损伤效应。
