Faculty of Educational Sciences, Open University of the Netherlands, the Netherlands, Heerlen 6419 AT, the Netherlands.
Omegametrix, Martinsried 82 152, Germany; Preventive Cardiology, Medical Clinic and Poli-Clinic I, Ludwig Maximilians-University Munich, 80336 Munich, Germany.
Prostaglandins Leukot Essent Fatty Acids. 2020 Dec;163:102208. doi: 10.1016/j.plefa.2020.102208. Epub 2020 Nov 12.
Observational studies have shown a relationship between omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) and depression in adolescents. However, n-3 LCPUFA supplementation studies investigating the potential improvement in depressive feelings in adolescents from the general population are missing.
A one-year double-blind, randomized, placebo controlled krill oil supplementation trial was conducted in two cohorts. Cohort I started with 400 mg eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) or placebo, after three months this increased to 800 mg EPA and DHA per day, whilst cohort II started with this higher dose. Omega-3 Index (O3I) was monitored via finger-prick blood measurements. At baseline, six and 12 months participants completed the Centre for Epidemiologic Studies Depression Scale (CES-D) and the Rosenberg Self Esteem questionnaire (RSE). Adjusted mixed models were run with treatment allocation/O3I as predictor of CES-D and RSE scores.
Both intention-to-treat and assessing the change in O3I analyses did not show significant effects on CES-D or RSE scores.
There is no evidence for less depressive feelings, or higher self-esteem after one year of krill oil supplementation. However, due to a lack of adherence and drop-out issues, these results should be interpreted with caution.
观察性研究表明，ω-3 长链多不饱和脂肪酸（n-3 LCPUFA）与青少年抑郁之间存在关联。然而，目前缺乏关于 n-3 LCPUFA 补充剂研究调查普通人群中青少年抑郁情绪改善的潜在作用。
在两个队列中进行了为期一年的双盲、随机、安慰剂对照的磷虾油补充试验。队列 I 最初服用 400mg 二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）或安慰剂，三个月后增加到每天 800mg EPA 和 DHA，而队列 II 则开始服用更高剂量。通过指尖采血测量监测ω-3 指数（O3I）。在基线、6 个月和 12 个月时，参与者完成了流行病学研究抑郁量表（CES-D）和罗森伯格自尊量表（RSE）。采用调整后的混合模型，以治疗分配/O3I 为预测因子，分析 CES-D 和 RSE 评分。
意向治疗和评估 O3I 变化的分析均未显示对 CES-D 或 RSE 评分有显著影响。
在服用磷虾油一年后，没有证据表明抑郁感减轻或自尊心提高。然而，由于缺乏依从性和辍学问题，这些结果应谨慎解释。
