Adriano Lia Silveira, Dionísio Ana Paula, Pinto de Abreu Fernando Antônio, Wurlitzer Nedio Jair, Cordeiro de Melo Bárbara Rebeca, Ferreira Carioca Antônio Augusto, de Carvalho Sampaio Helena Alves
Department of Nutrition, State University of Ceara, 60714-903 Fortaleza, CE, Brazil; Department of Nutrition, University of Fortaleza, 60811-905 Fortaleza, CE, Brazil.
Embrapa Agroindústria Tropical, Dra Sara Mesquita Street, 2270, 60511-110 Fortaleza, CE, Brazil.
Food Res Int. 2020 Nov;137:109648. doi: 10.1016/j.foodres.2020.109648. Epub 2020 Sep 3.
Yacon syrup is a rich source of fructooligosaccharides (FOS); however, its diet supplementation effect on subjective sensation and appetite biomarkers in human is still unknown. This study aimed to evaluate the acute postprandial effect of yacon syrup ingestion on appetite. The double-blind crossover clinical trial was carried out with 40 adult women: 20 eutrophic and 20 obese grade I. On each day, the first blood collection was performed after a 12-h fast. Then, the volunteers ingested either intervention A (breakfast + 40 g of placebo) or intervention B (breakfast + 40 g of yacon syrup, containing 14 g of FOS). New aliquots of blood were collected at 45, 60, 90, 120, and 180 min. Appetite was assessed by estimating ghrelin and glucagon-like peptide-1 (GLP-1) levels and by assessing subjective appetite sensation. Analysis was performed using two-way ANOVA, followed by Bonferroni's multiple comparison test. No effect of yacon syrup was observed on postprandial ghrelin and GLP-1 levels at all times evaluated. Similar observations were made after stratifying the analysis by BMI (body mass index) (eutrophic and obese). The effect of yacon syrup on postprandial subjective sensations of hunger, satiety, fullness, and desire to eat was not evident in the total group of women evaluated and even after BMI stratification. We concluded that yacon syrup had no effect on postprandial ghrelin and GLP-1 levels and on the subjective appetite sensation in young adult women.
雪莲果糖浆是低聚果糖（FOS）的丰富来源；然而，其对人体主观感觉和食欲生物标志物的饮食补充效果仍不清楚。本研究旨在评估摄入雪莲果糖浆后的急性餐后食欲影响。该双盲交叉临床试验对40名成年女性进行：20名营养良好者和20名I级肥胖者。每天，在禁食12小时后进行首次采血。然后，志愿者摄入干预A（早餐 + 40克安慰剂）或干预B（早餐 + 40克雪莲果糖浆，含14克低聚果糖）。在45、60、90、120和180分钟时采集新的血样。通过估计胃饥饿素和胰高血糖素样肽-1（GLP-1）水平以及评估主观食欲感觉来评估食欲。使用双向方差分析进行分析，随后进行Bonferroni多重比较检验。在所有评估时间点，均未观察到雪莲果糖浆对餐后胃饥饿素和GLP-1水平有影响。按体重指数（BMI）（营养良好和肥胖）分层分析后也得到了类似的结果。在评估的所有女性组中，甚至在按BMI分层后，雪莲果糖浆对餐后饥饿、饱腹感、饱足感和进食欲望的主观感觉均无明显影响。我们得出结论，雪莲果糖浆对年轻成年女性的餐后胃饥饿素和GLP-1水平以及主观食欲感觉没有影响。
