Hamami Hagai, Sheiner Eyal, Wainstock Tamar, Mazor Elad, Lanxner Battat Talya, Walfisch Asnat, Kosef Tamar, Pariente Gali
Faculty of Health Sciences, The Joyce and Irving Goldman Medical School, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
J Clin Med. 2020 Nov 20;9(11):3727. doi: 10.3390/jcm9113727.
Survivors of the 2003 SARS epidemic were found to have higher rates of adverse mental conditions. This study aimed to assess cognitive function in women delivering during the COVID-19 pandemic, as compared to women who delivered before the COVID-19 pandemic. A cohort study was performed during the immediate postpartum period of women delivering singletons at term. Cognitive function was assessed using an objective neurocognitive test (Symbol Digit Modalities Test SDMT90, SDMT4) and a subjective self-estimation questionnaire (Attention Function Index AFI). The exposed group was recruited during the COVID-19 outbreak in Israel (May 2020), whereas the comparison group consisted of women delivering at the same medical center before the COVID-19 pandemic (2016-2017). Multivariable regression models were constructed to control potential confounders. There were 79 parturients recruited during the COVID-19 pandemic and compared with 123 women who delivered before the COVID-19 pandemic. Women delivering during the COVID-19 pandemic scored lower in the subjective AFI test compared to the unexposed group (70.0 ± 15.4 vs. 75.1 ± 14.7, = 0.018). However, no significant difference was found in the objective SDMT tests scores. These results remained similar in the multivariable regression models when controlling for maternal age, ethnicity and time from admission to assessment, for AFI, SDMT90 and SDMT4 scores ( = 0.014; = 0.734; = 0.786; respectively). While no significant difference was found in objective tests, our findings propose that the exposure to the COVID-19 pandemic is independently associated with a significant decrease in subjective maternal cognitive function during the immediate postpartum period.
研究发现，2003年非典疫情的幸存者出现不良精神状况的几率更高。本研究旨在评估在新冠疫情期间分娩的女性与在新冠疫情之前分娩的女性相比的认知功能。对足月分娩单胎的女性在产后即刻进行了一项队列研究。使用客观神经认知测试（符号数字模态测试SDMT90、SDMT4）和主观自我评估问卷（注意力功能指数AFI）评估认知功能。暴露组是在以色列新冠疫情爆发期间（2020年5月）招募的，而对照组由在新冠疫情之前（2016 - 2017年）在同一医疗中心分娩的女性组成。构建多变量回归模型以控制潜在的混杂因素。在新冠疫情期间招募了79名产妇，并与123名在新冠疫情之前分娩的女性进行比较。与未暴露组相比，在新冠疫情期间分娩的女性在主观AFI测试中的得分较低（70.0±15.4 vs. 75.1±14.7，P = 0.018）。然而，在客观SDMT测试得分中未发现显著差异。在控制产妇年龄、种族和从入院到评估的时间后，对于AFI、SDMT90和SDMT4得分，这些结果在多变量回归模型中仍然相似（分别为P = 0.014；P = 0.734；P = 0.786）。虽然在客观测试中未发现显著差异，但我们的研究结果表明，在产后即刻，接触新冠疫情与产妇主观认知功能的显著下降独立相关。
