TAM 受体及其配体介导的激活：在动脉粥样硬化中的作用。
TAM receptors and their ligand-mediated activation: Role in atherosclerosis.
机构信息
Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Department of Pathology and Cell Biology, Columbia University, New York, NY, United States.
出版信息
Int Rev Cell Mol Biol. 2020;357:21-33. doi: 10.1016/bs.ircmb.2020.09.001. Epub 2020 Oct 5.
Abstract
TAM family tyrosine kinase receptors including Tyro3, Axl, and MerTK are the key efferocytosis receptors presenting on antigen-presenting cell that mediate the clearance of apoptotic cells. They are thought to regulate inflammatory diseases by modulating inflammatory response and efferocytosis. Recent studies have revealed novel roles of TAM receptors in the biosynthesis of specialized pro-resolving mediators (SPMs) and inflammation resolution. In this chapter, we discuss the central roles of TAM signaling in atherosclerosis focusing on their regulation in efferocytosis and inflammation resolution and highlight the unique therapeutic potential of SPMs in blocking the progression of atherosclerosis.
摘要
TAM 家族酪氨酸激酶受体包括 Tyro3、Axl 和 MerTK，是抗原呈递细胞上的关键吞噬作用受体，介导凋亡细胞的清除。它们被认为通过调节炎症反应和吞噬作用来调节炎症性疾病。最近的研究揭示了 TAM 受体在合成专门的促解决介质（SPM）和炎症解决中的新作用。在本章中，我们讨论了 TAM 信号在动脉粥样硬化中的核心作用，重点讨论了它们在吞噬作用和炎症解决中的调节作用，并强调了 SPM 在阻止动脉粥样硬化进展方面的独特治疗潜力。
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