Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow, UK.
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Cardiovasc Res. 2019 Jul 1;115(8):1286-1295. doi: 10.1093/cvr/cvz100.
The TAM receptors are a distinct family of three receptor tyrosine kinases, namely Tyro3, Axl, and MerTK. Since their discovery in the early 1990s, they have been studied for their ability to influence numerous diseases, including cancer, chronic inflammatory and autoimmune disorders, and cardiovascular diseases. The TAM receptors demonstrate an ability to influence multiple aspects of cardiovascular pathology via their diverse effects on cells of both the vasculature and the immune system. In this review, we will explore the various functions of the TAM receptors and how they influence cardiovascular disease through regulation of vascular remodelling, efferocytosis and inflammation. Based on this information, we will suggest areas in which further research is required and identify potential targets for therapeutic intervention.
TAM 受体是一组独特的三种受体酪氨酸激酶家族，分别为 Tyro3、Axl 和 MerTK。自 20 世纪 90 年代初发现以来，它们一直因其影响多种疾病的能力而受到研究，包括癌症、慢性炎症和自身免疫性疾病以及心血管疾病。TAM 受体通过对血管和免疫系统细胞的多种作用，显示出影响心血管病理学多个方面的能力。在这篇综述中，我们将探讨 TAM 受体的各种功能，以及它们如何通过调节血管重塑、细胞吞噬作用和炎症来影响心血管疾病。基于这些信息，我们将提出需要进一步研究的领域，并确定潜在的治疗干预靶点。
